Functions of SK channels in central neurons

Faber, E. S. L. and Sah, P. (2007) Functions of SK channels in central neurons. Clinical and Experimental Pharmacology and Physiology, 34 10: 1077-1083.


Author Faber, E. S. L.
Sah, P.
Title Functions of SK channels in central neurons
Journal name Clinical and Experimental Pharmacology and Physiology   Check publisher's open access policy
ISSN 0305-1870
Publication date 2007
Sub-type Article (original research)
DOI 10.1111/j.1440-1681.2007.04725.x
Volume 34
Issue 10
Start page 1077
End page 1083
Total pages 7
Editor W. P. Anderson
Place of publication Australia
Publisher Wiley-Blackwell Publishing Asia
Collection year 2008
Language eng
Subject 320704 Cellular Nervous System
730211 Mental health
C1
320799 Neurosciences not elsewhere classified
Abstract SK channels are small-conductance calcium-activated potassium channels that are widely expressed in neurons. The traditional view of the functional role of SK channels is in mediating one component of the after-hyperpolarization that follows action potentials. Calcium influx via voltage-gated calcium channels active during action potentials opens SK channels and the resultant hyperpolarization lowers the firing frequency of action potentials in many neurons. Recent advances have shown that, in addition to controlling action potential firing frequency, SK channels are also important in regulating dendritic excitability, synaptic transmission and synaptic plasticity. In accordance with their role in modulating synaptic plasticity, SK channels are also important in regulating several learning and memory tasks and may also play a role in a number of neurological disorders. The present review discusses recent findings on the role of SK channels in central neurons.
Keyword Pharmacology & Pharmacy
Physiology
Q-Index Code C1
Q-Index Status Confirmed Code

 
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Created: Thu, 01 May 2008, 12:46:52 EST by Debra McMurtrie on behalf of Queensland Brain Institute