Bone and prostate cancer cell interactions in metastatic prostate cancer

Vela, Ian, Gregory, Laura, Gardiner, Edith M., Clements, Judith A. and Nicol, David L. (2007) Bone and prostate cancer cell interactions in metastatic prostate cancer. BJU International, 99 4: 735-742. doi:10.1111/j.1464-410X.2006.06670.x


Author Vela, Ian
Gregory, Laura
Gardiner, Edith M.
Clements, Judith A.
Nicol, David L.
Title Bone and prostate cancer cell interactions in metastatic prostate cancer
Journal name BJU International   Check publisher's open access policy
ISSN 1464-4096
1464-410X
Publication date 2007-04
Year available 2006
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1111/j.1464-410X.2006.06670.x
Volume 99
Issue 4
Start page 735
End page 742
Total pages 8
Place of publication Oxford, United Kingdom
Publisher Wiley-Blackwell Publishing
Collection year 2008
Language eng
Subject C1
270105 Cellular Interactions (incl. Adhesion, Matrix, Cell Wall)
730108 Cancer and related disorders
Abstract The interplay in prostate cancer bone metastases between the 'seed' (the prostate cancer cells) and the 'soil' (the bone microenvironment) has been increasingly recognized as integral to the remarkable tropism for bone shown by prostate cancer. Increasing research into this area is elucidating the mechanisms involved in this complex 'cross-talk'. Recent developments, including the use of bisphosphonates in metastatic disease, highlight the important role of bone cells in the development and progression of metastatic prostate cancer. We review the current reports emphasising these possible mechanisms and indicating possible factors for future treatment directions.
Keyword Bone
Prostate
Cancer
Metastasis
Cross-talk
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published in section 'Mini-reviews'

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Excellence in Research Australia (ERA) - Collection
2008 Higher Education Research Data Collection
ERA 2012 Admin Only
School of Medicine Publications
UQ Diamantina Institute Publications
 
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Created: Wed, 30 Apr 2008, 12:35:37 EST by Kylie Hengst on behalf of UQ Diamantina Institute