Therapeutic applications of mesenchymal stromal cells

Brooke, Gary, Cook, Matthew, Blair, Chris, Han, Rachel, Heazlewood, Celena, Jones, Ben, Kambouris, Melinda, Kollar, Kate, McTaggart, Steven, Pelekanos, Rebecca, Rice, Alison, Rossetti, Tony and Atkinson, Kerry (2007) Therapeutic applications of mesenchymal stromal cells. Seminars in Cell & Developmental Biology, 18 6: 847-858. doi:10.1016/j.semcdb.2007.09.012

Author Brooke, Gary
Cook, Matthew
Blair, Chris
Han, Rachel
Heazlewood, Celena
Jones, Ben
Kambouris, Melinda
Kollar, Kate
McTaggart, Steven
Pelekanos, Rebecca
Rice, Alison
Rossetti, Tony
Atkinson, Kerry
Title Therapeutic applications of mesenchymal stromal cells
Journal name Seminars in Cell & Developmental Biology   Check publisher's open access policy
ISSN 1084-9521
Publication date 2007-12
Sub-type Article (original research)
DOI 10.1016/j.semcdb.2007.09.012
Volume 18
Issue 6
Start page 847
End page 858
Total pages 13
Editor J. Davey
Place of publication United Kingdom
Publisher Academic Press
Collection year 2008
Language eng
Subject 320205 Transplantation Immunology
730102 Immune system and allergy
Abstract Mesenchymal stromal cells (MSC) are multipotent cells that can be derived from many different organs and tissues. They have been demonstrated to play a role in tissue repair and regeneration in both preclinical and clinical studies. They also have remarkable immunosuppressive properties. We describe their application in settings that include the cardiovascular, central nervous, gastrointestinal, renal, orthopaedic and haematopoietic systems. Manufacturing of MSC for clinical trials is also discussed. Since tissue matching between MSC donor and recipient does not appear to be required, MSC may be the first cell type able to be used as an “off-the-shelf” therapeutic product.
Keyword Mesenchymal stromal cells
Mesenchymal stem cells
Therapeutic applications
Q-Index Code C1
Q-Index Status Confirmed Code

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Created: Mon, 28 Apr 2008, 15:14:26 EST by Maree Knight on behalf of Queensland Brain Institute