The origin of a Robertsonian chromosomal translocation in house mice inferred from linked microsatellite markers

Riginos, Cynthia and Nachman, Michael W. (1999) The origin of a Robertsonian chromosomal translocation in house mice inferred from linked microsatellite markers. Molecular Biology and Evolution, 16 12: 1763-1773.


Author Riginos, Cynthia
Nachman, Michael W.
Title The origin of a Robertsonian chromosomal translocation in house mice inferred from linked microsatellite markers
Journal name Molecular Biology and Evolution   Check publisher's open access policy
ISSN 0737-4038
1537-1719
Publication date 1999-01-01
Sub-type Article (original research)
Volume 16
Issue 12
Start page 1763
End page 1773
Total pages 11
Place of publication Lawrence, Kansas
Publisher Society for Molecular Biology and Evolution
Language eng
Subject 270000 Biological Sciences
270700 Ecology and Evolution
Abstract The Western European house mouse, Mus domesticus, includes many distinct Robertsonian (Rb) chromosomal races. Two competing hypotheses may explain the distribution of Rb translocations found in different populations: they may have arisen independently multiple times or they may have arisen once and been spread through long distance dispersal. We investigated the origin of the Rb 5.15 translocation using 6 microsatellite loci linked to the centromeres of chromosomes 5 and 15 in 84 individuals from 3 Rb populations and 4 neighboring standard-karyotype populations. Microsatellite variation on the 5.15 metacentric chromosomes was significantly reduced relative to the amount of variation found on acrocentric chromosomes 5 and 15, suggesting that linked microsatellite loci can track specific mutational events. Phylogenetic analyses resulted in trees which are consistent with multiple origins of the 5.15 metacentric found in the three Rb populations. These results suggest that cytologically indistinguishable mutations have arisen independently in natural populations of house mice.
Keyword evolution
microsatellite
Mus domesticus
Robertsonian translocation
speciation
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collections: School of Biological Sciences Publications
Ecology Centre Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 23 times in Thomson Reuters Web of Science Article | Citations
Google Scholar Search Google Scholar
Created: Mon, 30 Apr 2007, 09:11:52 EST by Dr Cynthia Riginos on behalf of School of Biological Sciences