Optimizing use of ß-lactum antibiotics in the critically ill

Roberts, Jason A. and Lipman, Jeffrey (2007) Optimizing use of ß-lactum antibiotics in the critically ill. Seminars in Respiratory and Critical Care Medicine, 28 6: 579-585. doi:10.1055/s-2007-996404

Author Roberts, Jason A.
Lipman, Jeffrey
Title Optimizing use of ß-lactum antibiotics in the critically ill
Journal name Seminars in Respiratory and Critical Care Medicine   Check publisher's open access policy
ISSN 1069-3424
Publication date 2007
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1055/s-2007-996404
Volume 28
Issue 6
Start page 579
End page 585
Total pages 7
Editor J.P. Lynch
Place of publication New York, U.S.A.
Publisher Thieme Medical Publishers
Collection year 2008
Language eng
Subject 730101 Infectious diseases
321009 Intensive Care
1102 Cardiovascular Medicine and Haematology
Abstract The escalation of serious infections in critically ill patients over the past 25 years has continued despite advances in contemporary medicine. Ongoing research to reduce the high morbidity and mortality rates is mandated. β-lactam antibiotics are often used empirically in serious infections. The efficacy of these time-dependent antibiotics is correlated with the time that concentrations are maintained above the minimum inhibitory concentration of the infective pathogen. In critically ill patients, pathophysiological changes can reduce antibiotic concentrations and thus alternative modes of administration such as continuous infusion have been studied and shown to standardize β-lactam pharmacokinetics and meet pharmacodynamic targets. Clinical data supporting the efficacy of continuous infusion are currently scarce, but data continue to grow. Likewise antibiotic resistance continues to grow. Recent data suggest that poor dosing strategies may be contributing to this problem, which is exacerbated by a lack of development of alternate antibiotics. Suffice to say clinicians must use antibiotic regimens that optimally treat the individual patient and reduce the development of antibiotic resistance. © Thieme Medical Publishers
Keyword β-lactam
Continuous infusion
Critically Ill
Q-Index Code C1
Q-Index Status Confirmed Code

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Excellence in Research Australia (ERA) - Collection
2008 Higher Education Research Data Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 10 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 12 times in Scopus Article | Citations
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Created: Thu, 24 Apr 2008, 13:51:05 EST by Sarah Elliott on behalf of Anaesthesiology and Critical Care - RBWH