Use of elastin fibres detected in non-directed low volume bronchial lavage in ventilated ICU patients

Boots, R. J., Phillips, G. E., George, N. and Faoagali, J. L. (2007) Use of elastin fibres detected in non-directed low volume bronchial lavage in ventilated ICU patients. Anaesthesia and Intensive Care, 35 2: 189-193.

Author Boots, R. J.
Phillips, G. E.
George, N.
Faoagali, J. L.
Title Use of elastin fibres detected in non-directed low volume bronchial lavage in ventilated ICU patients
Journal name Anaesthesia and Intensive Care   Check publisher's open access policy
ISSN 0310-057X
1448-0271
Publication date 2007-04-01
Sub-type Article (original research)
Volume 35
Issue 2
Start page 189
End page 193
Total pages 5
Editor A. W. Duncan
Place of publication Australia
Publisher Australia Society of Anaesthetists
Collection year 2008
Language eng
Subject 321009 Intensive Care
C1
730111 Hearing, vision, speech and their disorders
Formatted abstract
Elastin fibres in sputum have been described as a more sensitive marker of pulmonary necrosis than plain chest X-rays. This study aimed to determine the prevalence of elastin fibres using non-directed non-protected mini-bronchoalveolar lavage (BM-BAL) in mechanically ventilated patients in the intensive care unit. Patients admitted to the general intensive care unit of a tertiary referral hospital requiting more than 48 hours of mechanical ventilation had surveillance BM-BAL performed on admission and were then examined weekly using potassium hydroxide wet preparations for the presence of elastin fibres. All positive and a random selection of 16 negative preparations from patients with acute respiratory distress syndrome or pneumonia were fixed and examined using Weigert's staining method for elastin. Of 412 patients enrolled, 130 (32%) had pneumonia on admission, 50 (12%) developed 58 episodes of ventilator-associated pneumonia and acute respiratory distress syndrome was diagnosed in 86 patients (21 %). No chest X-ray showed cavitating infiltrates. Of 985 specimens examined, only seven had elastin fibres. Elastin fibres are uncommonly found using BM-BAL in general screening, acute respiratory distress syndrome or pneumonia in the intensive care unit, the incidence too low to be a useful indicator of pulmonary necrosis.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2008 Higher Education Research Data Collection
School of Medicine Publications
 
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Created: Thu, 24 Apr 2008, 21:48:14 EST by Sarah Elliott on behalf of Anaesthesiology and Critical Care - RBWH