The possibilities for intelligent transport systems (ITS) to address safety problems on airport ramps are examined. In addition, a structured approach to aid the safe design and implementation of such systems to aid injury prevention in different industry and transport domains are presented. The work begins by reviewing worldwide ramp accidents and incidents. Thereafter, it presents ramp safety data collected at an Australian international airport. Building on this identification of problems, the research shows that a large number of ITS devices are theoretically possible to address such safety issues, and then proposes criteria upon which decisions to implement such technology could be based. The paper closes by giving general recommendations for which of the identified ITS devices should be further deployed on airport ramps and makes overall conclusions regarding the further development of a structured approach to establish the injury prevention benefits of ITS in different domains.