Angiotensinogen and transforming growth factor beta 1 ; novel genes in the pathogenesis of Crohn's disease

Hume, G. E., Fowler, E. V., Lincoln, D., Eri, R., Templeton, D., Florin, T. H., Cavanaugh, J. A. and Radford-Smith, G. (2006) Angiotensinogen and transforming growth factor beta 1 ; novel genes in the pathogenesis of Crohn's disease. Journal of Medical Genetics, 43 10: 1-5.


Author Hume, G. E.
Fowler, E. V.
Lincoln, D.
Eri, R.
Templeton, D.
Florin, T. H.
Cavanaugh, J. A.
Radford-Smith, G.
Title Angiotensinogen and transforming growth factor beta 1 ; novel genes in the pathogenesis of Crohn's disease
Formatted title  Angiotensinogen and transforming growth factor β1 ; novel genes in the pathogenesis of Crohn's disease
Journal name Journal of Medical Genetics   Check publisher's open access policy
ISSN 0022-2593
1468-6244
Publication date 2006
Sub-type Letter to editor, brief commentary or brief communication
DOI 10.1136/jmg.2005.040477
Volume 43
Issue 10
Start page 1
End page 5
Total pages 5
Place of publication London, United Kingdom
Publisher BMJ Publishing Group
Collection year 2008
Language eng
Subject C1
270203 Population and Ecological Genetics
321006 Gastroenterology and Hepatology
730107 Inherited diseases (incl. gene therapy)
321001 Anaesthesiology
321011 Medical Genetics
730113 Digestive system and disorders
Formatted abstract Aims:
Conduct an Australian-based analysis of the angiotensinogen-6 variant in two independent inflammatory bowel disease (IBD) cohorts, and examine the role of angiotensinogen-6 and TGFß1 codon 25 variants in shaping Crohn’s disease phenotype.

Methods:
IBD Patients (Crohn’s disease = 347, ulcerative colitis = 147) and CD families (n = 148) from two cohorts, together with 185 healthy controls were genotyped for angiotensinogen-6. Genotype-phenotype analyses were performed for both angiotensinogen-6 and TGFß1 codon 25.

Results:
Angiotensinogen-6 AA genotype was significantly associated with Crohn's disease (p = 0.007, OR = 2.38, CI = 1.32–4.32) in cohort 1, but not in the smaller cohort 2 (p = 0.19). The association remained significant when the two cohorts were combined (p = 0.008), and in a TDT family analysis (p = 0.03). TGF 1 codon 25 was associated with stricturing Crohn’s disease (p = 0.01, OR = 2.63, CI = 1.16–5.88) and a shorter time to intestinal resection (p = 0.06).

Conclusions:

The association of the angiotensinogen-6 variant with Crohn’s disease supports a potential role for angiotensin-converting enzyme inhibitors and angiotensin II receptor antagonists in disease treatment. Abbreviations: ACE, angiotensin-converting enzyme; AII, angiotensin II; IBD, inflammatory bowel disease; PCR, polymerase chain reaction; RBWH, Royal Brisbane and Women’s Hospital; TNBS, trinitrobenzene sulphonic acid; TDT, transmission disequilibrium test; TGFß1, transforming growth factor ß1; TNF{alpha}, tumour necrosis factor {alpha}
Keyword Genetics & Heredity
Inflammatory-bowel-disease
Kappa-b
Susceptibility
Q-Index Code CX
Q-Index Status Confirmed Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Letter to editor, brief commentary or brief communication
Collections: Excellence in Research Australia (ERA) - Collection
2007 Higher Education Research Data Collection
2008 Higher Education Research Data Collection
School of Medicine Publications
 
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Created: Tue, 22 Apr 2008, 12:08:41 EST by Maree Knight on behalf of Medicine - Royal Brisbane and Women's Hospital