Orthologous MicroRNA genes are located in cancer-associated genomic regions in human and mouse

Makunin, Igor, Pheasant, Michael, Simons, Cas and Mattick, John S. (2007) Orthologous MicroRNA genes are located in cancer-associated genomic regions in human and mouse. PLoS One, 2 11: . doi:10.1371/journal.pone.0001133


Author Makunin, Igor
Pheasant, Michael
Simons, Cas
Mattick, John S.
Title Orthologous MicroRNA genes are located in cancer-associated genomic regions in human and mouse
Journal name PLoS One   Check publisher's open access policy
ISSN 1932-6203
Publication date 2007-11-01
Sub-type Article (original research)
DOI 10.1371/journal.pone.0001133
Open Access Status DOI
Volume 2
Issue 11
Total pages 7
Place of publication San Francisco
Publisher Public Library Science
Collection year 2008
Language eng
Subject C1
321015 Oncology and Carcinogenesis
780108 Behavioural and cognitive sciences
Formatted abstract
Background

MicroRNAs (miRNAs) are short non-coding RNAs that regulate differentiation and development in many organisms and play an important role in cancer.

Methodology/Principal Findings


Using a public database of mapped retroviral insertion sites from various mouse models of cancer we demonstrate that MLV-derived retroviral inserts are enriched in close proximity to mouse miRNA loci. Clustered inserts from cancer-associated regions (Common Integration Sites, CIS) have a higher association with miRNAs than non-clustered inserts. Ten CIS-associated miRNA loci containing 22 miRNAs are located within 10 kb of known CIS insertions. Only one CIS-associated miRNA locus overlaps a RefSeq protein-coding gene and six loci are located more than 10 kb from any RefSeq gene. CIS-associated miRNAs on average are more conserved in vertebrates than miRNAs associated with non-CIS inserts and their human homologs are also located in regions perturbed in cancer. In addition we show that miRNA genes are enriched around promoter and/or terminator regions of RefSeq genes in both mouse and human.

Conclusions/Significance


We provide a list of ten miRNA loci potentially involved in the development of blood cancer or brain tumors. There is independent experimental support from other studies for the involvement of miRNAs from at least three CIS-associated miRNA loci in cancer development.
Q-Index Code C1
Q-Index Status Confirmed Code
Additional Notes Article number: e1133

 
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Created: Tue, 22 Apr 2008, 19:42:53 EST by Jennifer Greder on behalf of Institute for Molecular Bioscience