B-vitamins reduce plasma levels of beta amyloid

Flicker, Leon, Martins, Ralph N., Thomas, Jenny, Acres, John, Taddei, Kevin, Vasikaren, Samuel D., Norman, Paul, Jamrozik, Konrad and Almeida, Osvaldo P. (2008) B-vitamins reduce plasma levels of beta amyloid. Neurobiology of Aging, 29 2: 303-305. doi:10.1016/j.neurobiolaging.2006.10.007

Author Flicker, Leon
Martins, Ralph N.
Thomas, Jenny
Acres, John
Taddei, Kevin
Vasikaren, Samuel D.
Norman, Paul
Jamrozik, Konrad
Almeida, Osvaldo P.
Title B-vitamins reduce plasma levels of beta amyloid
Journal name Neurobiology of Aging   Check publisher's open access policy
ISSN 0197-4580
Publication date 2008-02
Year available 2006
Sub-type Article (original research)
DOI 10.1016/j.neurobiolaging.2006.10.007
Volume 29
Issue 2
Start page 303
End page 305
Total pages 3
Editor P. D. Coleman
Place of publication Philadelphia, United States
Publisher Elsevier
Collection year 2008
Language eng
Subject 321206 Preventive Medicine
730299 Public health not elsewhere classified
Abstract Elevated plasma homocysteine (tHcy) is a risk factor for Alzheimer's disease (AD), and thus B vitamins may have a role in the prevention of AD. The objective of this study was to determine if tHcy lowering vitamins decrease the circulating levels of A-beta protein 1–40 (Aβ40). We randomized 299 older men to treatment with 2 mg of folate, plus 25 mg of B6 and 400 μg of B12, or placebo. After 2 years of treatment the mean (S.E.) increase of Aβ40 was 7.0 pg/ml (8.4) in the vitamin group (4.9%), and 26.8 pg/ml (7.7) (18.5%) in the placebo group. We conclude that B vitamins may decrease the plasma level of Aβ40 and have a role in the prevention of AD.
Keyword Alzheimer
B vitamins
Amyloid beta protein
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2008 Higher Education Research Data Collection
School of Public Health Publications
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Citation counts: TR Web of Science Citation Count  Cited 24 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 27 times in Scopus Article | Citations
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Created: Mon, 07 Apr 2008, 15:36:17 EST by Ingrid Elvy on behalf of School of Public Health