Distribution, expression, and motif variability of ankyrin domain genes in Wolbachia pipientis

Iturbe-Ormaetxe, Inaki, Burke, Gaelen R., Riegler, Markus and O'Neill, Scott L. (2005) Distribution, expression, and motif variability of ankyrin domain genes in Wolbachia pipientis. Journal of Bacteriology, 187 15: 5136-5145. doi:10.1128/JB.187.15.5136-5145.2005

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Author Iturbe-Ormaetxe, Inaki
Burke, Gaelen R.
Riegler, Markus
O'Neill, Scott L.
Title Distribution, expression, and motif variability of ankyrin domain genes in Wolbachia pipientis
Journal name Journal of Bacteriology   Check publisher's open access policy
ISSN 0021-9193
Publication date 2005-08
Sub-type Article (original research)
DOI 10.1128/JB.187.15.5136-5145.2005
Open Access Status File (Publisher version)
Volume 187
Issue 15
Start page 5136
End page 5145
Total pages 10
Editor Graham C. Walker
Place of publication Washington, DC, United States
Publisher American Society for Microbiology
Collection year 2005
Language eng
Abstract The endosymbiotic bacterium Wolbachia pipientis infects a wide range of arthropods, in which it induces a variety of reproductive phenotypes, including cytoplasmic incompatibility (CI), parthenogenesis, male killing, and reversal of genetic sex determination. The recent sequencing and annotation of the first Wolbachia genome revealed an unusually high number of genes encoding ankyrin domain (ANK) repeats. These ANK genes are likely to be important in mediating the Wolbachia-host interaction. In this work we determined the distribution and expression of the different ANK genes found in the sequenced Wolbachia wMel genome in nine Wolbachia strains that induce different phenotypic effects in their hosts. A comparison of the ANK genes of wMel and the non-CI-inducing wAu Wolbachia strain revealed significant differences between the strains. This was reflected in sequence variability in shared genes that could result in alterations in the encoded proteins, such as motif deletions, amino acid insertions, and in some cases disruptions due to insertion of transposable elements and premature stops. In addition, one wMel ANK gene, which is part of an operon, was absent in the wAu genome. These variations are likely to affect the affinity, function, and cellular location of the predicted proteins encoded by these genes.
Keyword Microbiology
Induced Cytoplasmic Incompatibility
Unidirectional Incompatibility
Q-Index Code C1
Additional Notes Ranked Journal

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