Picoliter viscometry using optically rotated particles

Simon Parkin, Gregor Knoener, Nieminen, Timo A., Heckenberg, Norman R. and Rubinsztein-Dunlop, Halina (2007) Picoliter viscometry using optically rotated particles. Physical Review E, 76 4: 041507-1-041507-5. doi:10.1103/PhysRevE.76.041507

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Author Simon Parkin
Gregor Knoener
Nieminen, Timo A.
Heckenberg, Norman R.
Rubinsztein-Dunlop, Halina
Title Picoliter viscometry using optically rotated particles
Journal name Physical Review E   Check publisher's open access policy
ISSN 1539-3755
Publication date 2007-10-26
Year available 2007
Sub-type Article (original research)
DOI 10.1103/PhysRevE.76.041507
Open Access Status File (Publisher version)
Volume 76
Issue 4
Start page 041507-1
End page 041507-5
Total pages 5
Editor Gary S. Grest
Margaret Malloy
Place of publication United States
Publisher American Physical Society
Collection year 2008
Language eng
Subject 249999 Physical Sciences not elsewhere classified
780102 Physical sciences
240400 Optical Physics
240502 Fluid Physics
249901 Biophysics
249903 Instruments and Techniques
Abstract Important aspects in the field of microrheology are the studies of the viscosity of fluids within structures with micron dimensions and fluid samples where only microlitre volumes are available. We have quantitatively investigated the performance and accuracy of a microviscometer based on rotating optical tweezers, that requires as little as one microlitre of sample. We have characterised our microviscometer, including effects due to heating, and demonstrated its ability to perform measurements over a large dynamic range of viscosities (at least two orders of magnitude). We have also inserted a probe particle through the membrane of a cell and measured the viscosity of the intramembranous contents. Viscosity measurements of tears have also been made with our microviscometer, which demonstrate its potential use to study un-stimulated eye fluid.
Keyword optical tweezers
Q-Index Code C1

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Created: Tue, 01 Apr 2008, 14:52:53 EST by Jo Hughes on behalf of Centre for Biophotonics and Laser Science