Tissue Doppler in critical illness: A retrospective cohort study

Sturgess, David J., Marwick, Thomas H., Joyce, Christopher J., Jones, Mark and Venkatesh, Bala (2007) Tissue Doppler in critical illness: A retrospective cohort study. Critical Care, 11 5: R97-R104. doi:10.1186/cc6114

Author Sturgess, David J.
Marwick, Thomas H.
Joyce, Christopher J.
Jones, Mark
Venkatesh, Bala
Title Tissue Doppler in critical illness: A retrospective cohort study
Journal name Critical Care   Check publisher's open access policy
ISSN 1364-8535
Publication date 2007
Sub-type Article (original research)
DOI 10.1186/cc6114
Open Access Status DOI
Volume 11
Issue 5
Start page R97
End page R104
Total pages 8
Place of publication London, U.K.
Publisher BioMed Central
Language eng
Subject 110201 Cardiology (incl. Cardiovascular Diseases)
1102 Cardiovascular Medicine and Haematology
Formatted abstract
There is a paucity of published data on tissue Doppler imaging (TDI) in the critically ill. In a critically ill cohort, we studied the distribution of TDI and its correlation with other echocardiographic indices of preload. To aid hypothesis generation and sample size calculation, associations between echocardiographic variables, including the ratio of peak early diastolic transmitral velocity (E) to peak early diastolic mitral annular velocity (E'), and mortality were also explored.


This retrospective study was performed in a combined medical/surgical, tertiary referral intensive care unit. Over a 2-year period, 94 consecutive patients who underwent transthoracic echocardiography with E/E' measurement were studied.


Mean Acute Physiology and Chronic Health Evaluation III score was 72 ± 25. Echocardiography was performed 5 ± 6 days after intensive care unit admission. TDI variables exhibited a wide range (E' 4.7–18.2 cm/s and E/E' 3.3 to 27.2). E' below 9.6 cm/s was observed in 63 patients (rate of myocardial relaxation below lower 95% confidence limit of normal individuals). Fourteen patients had E/E' above 15 (evidence of raised left ventricular filling pressure). E/E' correlated with left atrial area (r = 0.27, P = 0.01) but not inferior vena cava diameter (r = 0.16, P = 0.21) or left ventricular end-diastolic volume (r = 0.16, P = 0.14). In this cohort, increased left ventricular end-systolic volume, but not E/E', appeared to be an independent predictor (odds ratio 2.1, P = 0.007) of 28-day mortality (31%; n = 29).


There was a wide range of TDI values. TDI evidence of diastolic dysfunction was common. E/E' did not correlate strongly with other echocardiographic indices of preload. Further evaluation of echocardiographic variables, particularly left ventricular end-systolic volume, for risk stratification in the critically ill appears warranted.
Keyword Tissue Doppler Imaging
Critically ill patients
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Public Health Publications
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Created: Fri, 28 Mar 2008, 17:00:14 EST