Measuring the burden of neglected tropical diseases: The global burden of disease framework

Mathers, Colin D., Ezzati, Majid and Lopez, Alan D. (2007) Measuring the burden of neglected tropical diseases: The global burden of disease framework. PLoS Neglected Tropical Diseases, 1 2: e114.1-e114.15. doi:10.1371/journal.pntd.0000114

Author Mathers, Colin D.
Ezzati, Majid
Lopez, Alan D.
Title Measuring the burden of neglected tropical diseases: The global burden of disease framework
Journal name PLoS Neglected Tropical Diseases   Check publisher's open access policy
ISSN 1935-2727
Publication date 2007
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1371/journal.pntd.0000114
Open Access Status DOI
Volume 1
Issue 2
Start page e114.1
End page e114.15
Total pages 15
Editor Hotez, P.
Place of publication San Francisco, CA, United States
Publisher Public Library of Science
Collection year 2008
Language eng
Subject C1
321202 Epidemiology
730212 Disease distribution and transmission
Abstract Reliable, comparable information about the main causes of disease and injury in populations, and how these are changing, is a critical input for debates about priorities in the health sector. Traditional sources of information about the descriptive epidemiology of diseases, injuries, and risk factors are generally incomplete, fragmented, and of uncertain reliability and comparability. The Global Burden of Disease (GBD) study has provided a conceptual and methodological framework to quantify and compare the health of populations using a summary measure of both mortality and disability, the disability-adjusted life year (DALY).This paper describes key features of the Global Burden of Disease analytic approach, which provides a standardized measurement framework to permit comparisons across diseases and injuries, as well as risk factors, and a systematic approach to the evaluation of data. The paper describes the evolution of the GBD, starting from the first study for the year 1990, summarizes the methodological improvements incorporated into GBD revisions for the years 2000-2004 carried out by the World Health Organization, and examines priorities and issues for the next major GBD study, funded by the Bill & Melinda Gates Foundation, and commencing in 2007.The paper presents an overview of summary results from the Global Burden of Disease study 2002, with a particular focus on the neglected tropical diseases, and also an overview of the comparative risk assessment for 26 global risk factors. Taken together, trypanosomiasis, Chagas disease, schistosomiasis, leishmaniasis, lymphatic filariasis, onchocerciasis, intestinal nematode infections, Japanese encephalitis, dengue, and leprosy accounted for an estimated 177,000 deaths worldwide in 2002, mostly in sub-Saharan Africa, and about 20 million DALYs, or 1.3% of the global burden of disease and injuries. Further research is currently underway to revise and update these estimates.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Excellence in Research Australia (ERA) - Collection
2008 Higher Education Research Data Collection
School of Public Health Publications
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Citation counts: TR Web of Science Citation Count  Cited 211 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 243 times in Scopus Article | Citations
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Created: Fri, 28 Mar 2008, 16:55:18 EST