Prevalence, intensity and associated morbidity of Schistosoma japonicum infection in the Dongting Lake region, China

Balen, Julie, Zhao, Zheng-Yuan, Williams, Gail M., McManus, Donald P., Raso, Giovanna, Utzinger, Jurg, Zhou, Jie and Li, Yue-Sheng (2007) Prevalence, intensity and associated morbidity of Schistosoma japonicum infection in the Dongting Lake region, China. Bulletin of the World Health Organization, 85 7: 519-526. doi:10.2471/BLT.06.034033


Author Balen, Julie
Zhao, Zheng-Yuan
Williams, Gail M.
McManus, Donald P.
Raso, Giovanna
Utzinger, Jurg
Zhou, Jie
Li, Yue-Sheng
Title Prevalence, intensity and associated morbidity of Schistosoma japonicum infection in the Dongting Lake region, China
Formatted title
Prevalence, intensity and associated morbidity of Schistosoma japonicum infection in the Dongting Lake region, China
Journal name Bulletin of the World Health Organization   Check publisher's open access policy
ISSN 0042-9686; 0043-9686
Publication date 2007-07
Sub-type Article (original research)
DOI 10.2471/BLT.06.034033
Volume 85
Issue 7
Start page 519
End page 526
Total pages 8
Editor H. Momen
L. Gollogly
Place of publication Geneva, Switzerland
Publisher World Health Organisation
Collection year 2008
Language eng
Subject 11 Medical and Health Sciences
C1
300504 Immunology
300508 Parasitology
730299 Public health not elsewhere classified
Formatted abstract
Objective To determine the prevalence and intensity of Schistosoma japonicum infection and associated morbidity, and to estimate the infected human and buffalo populations in the Dongting Lake region, Hunan province, China.

Methods We used data from the third national schistosomiasis periodic epidemiological survey (PES) of 2004. These included 47 144 human serological and 7205 stool examinations, 3893 clinical examinations and questionnaire surveys, and 874 buffalo stool examinations, carried out in 47 villages in Hunan province. Serological examinations were performed using the enzyme linked immunosorbent assay technique and human stool samples were examined by the Kato-Katz method. Stools from buffaloes and other domestic animals were examined for schistosome infection by the miracidial hatching test.

Findings Sero-prevalence was 11.9% (range: 1.3–34.9% at the village level), and the rate of egg-positive stools was estimated at 1.9% (0–10.9%) for the same population. The prevalence of infection among buffaloes was 9.5% (0–66.7%). Extrapolating to the entire population of the Dongting Lake region, an estimated 73 225 people and 13 973 buffaloes were infected. Most frequently reported symptoms were abdominal pain (6.2%) and bloody stools (2.7%). More than half of the clinically examined people reported having had at least one prior antischistosomal treatment.

Conclusion
There was a significant reduction in the number of humans infected with S. japonicum since the previous national PES carried out in 1995, partially explained by large-scale chemotherapy campaigns. However, a near-stable number of buffalo infections suggest continuing human re-infection, which may lead to future increases in human prevalence.
Keyword Public, Environmental & Occupational Health
Republic-of-china
Hunan Province
Public-health
Transmission
Diseases
Impact
World
Immunodiagnosis
Surveillance
Prospects
Q-Index Code C1

 
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Created: Fri, 28 Mar 2008, 16:38:15 EST