Implication of a Plasmodium falciparum gene in the switch between asexual reproduction and gametocytogenesis

Gardiner, Donald L., Dixon, Matthew W. A., Spielmann, Tobias, Skinner-Adams, Tina S., Hawthorne, Paula L., Ortega, Maria R., Kemp, David J. and Trenholme, Katharine R. (2005) Implication of a Plasmodium falciparum gene in the switch between asexual reproduction and gametocytogenesis. Molecular and Biochemical Parasitology, 140 2: 153-160. doi:10.1016/j.molbiopara.2004.12.010


Author Gardiner, Donald L.
Dixon, Matthew W. A.
Spielmann, Tobias
Skinner-Adams, Tina S.
Hawthorne, Paula L.
Ortega, Maria R.
Kemp, David J.
Trenholme, Katharine R.
Title Implication of a Plasmodium falciparum gene in the switch between asexual reproduction and gametocytogenesis
Journal name Molecular and Biochemical Parasitology   Check publisher's open access policy
ISSN 0166-6851
Publication date 2005
Sub-type Article (original research)
DOI 10.1016/j.molbiopara.2004.12.010
Volume 140
Issue 2
Start page 153
End page 160
Total pages 8
Place of publication Amsterdam, The Netherlands
Publisher Elsevier Science B.V.
Language eng
Subject 270100 Biochemistry and Cell Biology
11 Medical and Health Sciences
1108 Medical Microbiology
06 Biological Sciences
0605 Microbiology
Abstract Gametocytogenesis is fundamental for transmission of the malaria parasite Plasmodium falciparum from the human host to the mosquito vector, yet very little is understood about what triggers the switch between asexual reproduction and gametocytogenesis. Arresting the progression through the sexual cycle would block transmission of this disease. Here we identify a novel gene in P. falciparum that when genetically silenced reduces gametocyte production by a factor of 6, and when complemented up-regulates gametocyte-specific gene transcription. (c) 2005 Elsevier B.V. All rights reserved.
Keyword Biochemistry & Molecular Biology
Parasitology
Plasmodium falciparum
Gametocytogenesis
Chromosome 9
Transfection
Malaria Parasite
Infected Erythrocytes
Transfection Vectors
Protein
Chromosome-9
Cytoadherence
Gametocytes
Commitment
Induction
Invitro
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Public Health Publications
UQ Diamantina Institute Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 22 times in Thomson Reuters Web of Science Article | Citations
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Created: Fri, 28 Mar 2008, 15:28:19 EST