CLAG 9 is located in the rhoptries of Plasmodium falciparum

Gardiner, Donald L., Spielmann, Tobias, Dixon, Matthew W. A., Hawthorne, Paula L., Ortega, Maria R., Anderson, Karen L., Skinner-Adams, Tina S., Kemp, David J. and Trenholme, Katharine R. (2004) CLAG 9 is located in the rhoptries of Plasmodium falciparum. Parasitology Research, 93 1: 64-67. doi:10.1007/s00436-004-1098-4


Author Gardiner, Donald L.
Spielmann, Tobias
Dixon, Matthew W. A.
Hawthorne, Paula L.
Ortega, Maria R.
Anderson, Karen L.
Skinner-Adams, Tina S.
Kemp, David J.
Trenholme, Katharine R.
Title CLAG 9 is located in the rhoptries of Plasmodium falciparum
Formatted title
CLAG 9 is located in the rhoptries of Plasmodium falciparum
Journal name Parasitology Research   Check publisher's open access policy
ISSN 0932-0113
1432-1955
Publication date 2004-05
Sub-type Article (original research)
DOI 10.1007/s00436-004-1098-4
Volume 93
Issue 1
Start page 64
End page 67
Total pages 4
Place of publication New York, U.S.A.
Publisher Springer-verlag
Language eng
Subject 320000 Medical and Health Sciences
1108 Medical Microbiology
Formatted abstract
Clag 9, a gene located on chromosome 9 of Plasmodium falciparum has previously been associated with the cytoadherence of parasitized erythrocytes to CD36. This gene is part of a multi-gene family found in all Plasmodium species studied to date. Using data from the Malaria Genome Sequencing Project, peptides specific for clag 9 were designed, synthesized and used to immunize mice. This antisera was used in Western blotting and immunofluorescence experiments to determine the cellular localization of CLAG 9 in the parasitized erythrocyte. Co-localization using immunofluorescence of wildtype and knockout parasites unequivocally shows that CLAG 9 is localized to the rhoptry organelles of P. falciparum.
Keyword Parasitology
Gene-function
Erythrocytes
Protein
Cytoadherence
Membrane
Family
Q-Index Code C1

 
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Created: Fri, 28 Mar 2008, 15:25:07 EST