Broth recycling to reduce process noise resulting from concentrated substrate addition in fed-batch cultivation of Escherichaa coli

Johnston, W. A. and Cooney, M. J. (2003) Broth recycling to reduce process noise resulting from concentrated substrate addition in fed-batch cultivation of Escherichaa coli. Biotechnology Progress, 19 2: 659-661.


Author Johnston, W. A.
Cooney, M. J.
Title Broth recycling to reduce process noise resulting from concentrated substrate addition in fed-batch cultivation of Escherichaa coli
Journal name Biotechnology Progress  (ERA 2012 Listed)    (ERA 2010 Rank A)   Check publisher's open access policy
Publication date 2003
Sub-type Article
DOI 10.1021/bp025659i
Volume number 19
Issue number 2
ISSN 8756-7938
Start page 659
End page 661
Total pages 3
Place of publication Washington
Publisher American Chemical Society
Language eng
Subject 270300 Microbiology
270800 Biotechnology
Abstract In this work feed hardware for fed-batch cultivation is presented (broth recycle feed injection system or BRFIS). BRFIS proved superior to conventional submerged or dripped feed systems in reducing dissolved oxygen (DO) oscillations during Escherichia coli fed-batch cultivation (5 min coefficient of variation of 0.7% for BRFIS as compared to 26% or greater for conventional feeding hardware in a 2 L test reactor). Hence, BRFIS is useful for fed-batch cultivation systems where the DO signal is used in measurement or control.
Keyword Biotechnology & Applied Microbiology
Food Science & Technology
Cultures
Glucose
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article
Collections: Excellence in Research Australia (ERA) - Collection
School of Biomedical Sciences Publications
 
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