Expression profiling in monozygotic twins discordant for bipolar disorder reveals dysregulation of the WNT signaling pathway

Matigian, N., Windus, L., Smith, H., Fillipich, C., Pantelis, C., McGrath, J. J., Mowry, B. and Hayward, N. (2007) Expression profiling in monozygotic twins discordant for bipolar disorder reveals dysregulation of the WNT signaling pathway. Molecular Psychiatry, 12 9: 815-825. doi:10.1038/sj.mp.4001998


Author Matigian, N.
Windus, L.
Smith, H.
Fillipich, C.
Pantelis, C.
McGrath, J. J.
Mowry, B.
Hayward, N.
Title Expression profiling in monozygotic twins discordant for bipolar disorder reveals dysregulation of the WNT signaling pathway
Journal name Molecular Psychiatry   Check publisher's open access policy
ISSN 1359-4184
Publication date 2007-09-01
Year available 2007
Sub-type Article (original research)
DOI 10.1038/sj.mp.4001998
Volume 12
Issue 9
Start page 815
End page 825
Total pages 21
Place of publication United Kingdom
Publisher Nature Publishing Group
Collection year 2008
Language eng
Subject 321204 Mental Health
C1
730211 Mental health
Abstract To identify genes dysregulated in bipolar disorder (BD1), we carried out global gene expression profiling using whole-genome microarrays. To minimize genetic variation in gene expression levels between cases and controls, we compared expression profiles in lymphoblastoid cell lines from monozygotic twin pairs discordant for the disease. We identified 82 genes that were differentially expressed by greater than or equal to1.3-fold in three BD1 cases compared to their co-twins, and which were statistically (Pless than or equal to0.05) differentially expressed between the groups of BD1 cases and controls. Using quantitative reverse transcriptase-polymerase chain reaction, we confirmed the differential expression of some of these genes, including: KCNK1, MAL, PFN2, TCF7, PGK1 and PI4KCB, in at least two of the twin pairs. In contrast to the findings of a previous study by Kakiuchi and colleagues with similar discordant BD1 twin design, our data do not support the dysregulation of XBP1 and HSPA5. From pathway and gene ontology analysis, we identified upregulation of the WNT signalling pathway and the biological process of apoptosis. The differentially regulated genes and pathways identified in this study may provide insights into the biology of BD1.
Keyword apoptosis
bipolar disorder
microarrays
monozygotic twins
WNT pathway
Q-Index Code C1
Q-Index Status Confirmed Code

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2008 Higher Education Research Data Collection
School of Medicine Publications
 
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Created: Fri, 28 Mar 2008, 02:10:09 EST by Carmel Meir on behalf of Psychiatry - Princess Alexandra Hospital