The EPPIC long term follow-up study of first episode psychosis: Clinical and functional outcomes at 7.5 years

Henry, L.P., Harris, M.G, Amminger, G.P., Jackson, H.J., Yuen, H.P., Harrigan, S.M. and McGorry, P.D. (2007). The EPPIC long term follow-up study of first episode psychosis: Clinical and functional outcomes at 7.5 years. In: Schizophrenia Bulletin. 11th International Congress on Schizophrenia Research, Colorado Springs, Colorado, USA, (590-590). March 28 - April 2, 2007. doi:10.1093/schbul/sbm004

Author Henry, L.P.
Harris, M.G
Amminger, G.P.
Jackson, H.J.
Yuen, H.P.
Harrigan, S.M.
McGorry, P.D.
Title of paper The EPPIC long term follow-up study of first episode psychosis: Clinical and functional outcomes at 7.5 years
Conference name 11th International Congress on Schizophrenia Research
Conference location Colorado Springs, Colorado, USA
Conference dates March 28 - April 2, 2007
Proceedings title Schizophrenia Bulletin   Check publisher's open access policy
Journal name Schizophrenia Bulletin   Check publisher's open access policy
Place of Publication Oxford, United Kingdom
Publisher Oxford Journals
Publication Year 2007
DOI 10.1093/schbul/sbm004
ISSN 0586-7614
Volume 33
Issue 2
Start page 590
End page 590
Total pages 1
Language eng
Abstract/Summary The purpose of this study is to examine the long-term clinical and functional outcome of first-episode psychosis (FEP). The study was a naturalistic, prospective follow-up of a large epidemiologically representative sample of 765 FEP patients, mean 7.4-years after initial presentation to a specialist early psychosis service (EPPIC) in Melbourne, Australia. Standardised assessments were used at the followup to assess participants’ demographic characteristics, axis I diagnosis, psychopathology and level of work and social functioning. Follow-up interviews were conducted on 511 participants; 133 refused; 39 were deceased and 82 were un-contactable. No participant bias due to study attrition was found. Some 230 (45.0%) of the interviewed group, met DSM-IV criteria of a current psychotic disorder; 281 (55.0%) individuals received a lifetime diagnosis of psychotic disorder. Numbers of individuals diagnosed with schizophrenia, schizoaffective disorder, affective psychosis and other psychosis, were 306 (59.6%), 48 (9.4%), 110 (21.5%) and 47 (9.2%), respectively. Comparisons between the diagnostic groups found the schizophrenia group to have significantly higher BPRS (total, psychotic subscale) and SANS (total) mean scores and significantly lower GAF, SOFAS and QLS mean scores than the other diagnostic groups at follow-up. The prevalence of current psychotic disorder was significantly higher in the schizophrenia group (60.1%) as compared to the other diagnostic groups (χ2=78.4, df=3, p<0.001). Considering the course of the psychotic disorder over the most recent two years, the majority (49.1%) reported that they have never been actively psychotic, 31.6% reported a continuous course, 17.1% reported an episodic course and 2.2% individuals neither episodic nor continuous course of illness. In contrast to previous medium and longer term follow-up studies of first episode schizophrenia where 19-37% were reported to be occupationally engaged,(and 10-15% of those with established schizophrenia in Australia) the proportion of individuals observed in this study with some level of employment in the last two years was substantially higher (schizophrenia, 52%; affective psychosis, 74.5%; schizoaffective, 60.4%; and other psychotic group, 72.3%). Findings from the EPPIC long term follow-up study emphasis that a specialised early intervention service program might result in better functional outcomes in contrast to previous assumptions, especially for those with schizophrenia.
Subjects 321204 Mental Health
730211 Mental health
1103 Clinical Sciences
1117 Public Health and Health Services
Keyword EPPIC
Psychotic disorder
First episode psychosis
Q-Index Code EX

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Created: Thu, 27 Mar 2008, 08:55:07 EST by Carmel Meir on behalf of Faculty Of Health Sciences