The p75 neurotrophin receptor

Underwood, Clare K. and Coulson, Elizabeth J. (2008) The p75 neurotrophin receptor. The International Journal of Biochemistry and Cell Biology, 40 9: 1664-1668. doi:10.1016/j.biocel.2007.06.010

Author Underwood, Clare K.
Coulson, Elizabeth J.
Title The p75 neurotrophin receptor
Journal name The International Journal of Biochemistry and Cell Biology   Check publisher's open access policy
ISSN 1357-2725
Publication date 2008
Year available 2007
Sub-type Article (original research)
DOI 10.1016/j.biocel.2007.06.010
Volume 40
Issue 9
Start page 1664
End page 1668
Total pages 5
Editor G. J. Laurent
Place of publication Oxford, United Kingdom
Publisher Pergamon
Collection year 2008
Language eng
Subject 320704 Cellular Nervous System
780105 Biological sciences
Abstract The pan neurotrophin receptor (p75(NTR)) is best known for mediating neural cell death during development as well as in the adult following injury, the latter making it a target for the treatment of neurodegenerative disease. Although p75(NTR) has been studied for over 30 years, a number of recent discoveries have changed our understanding of its regulation. Here we provide a brief overview of the p75(NTR) protein, its post-translational modifications, and the phenotype of p75(NTR)-deficient mice as a starting point for researchers unfamiliar with this complex receptor. The accepted mechanisms underlying the ability of p75(NTR) to regulate cell death as well as a number of other neural functions, most notably neuronal differentiation, neurite outgrowth and synaptic plasticity, are also summarised.
Keyword Apoptosis
Regulated intramembranous proteolysis
Receptor signaling
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Available online 30 June 2007

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Created: Wed, 19 Mar 2008, 09:52:39 EST