Prolonged anticholinergic delirium following antihistamine overdose

Scott, James, Pache, David, Keane, Greg, Buckle, Helen and O'Brien, Natalie (2007) Prolonged anticholinergic delirium following antihistamine overdose. Australasian Psychiatry, 15 3: 242-244. doi:10.1080/10398560601147020

Author Scott, James
Pache, David
Keane, Greg
Buckle, Helen
O'Brien, Natalie
Title Prolonged anticholinergic delirium following antihistamine overdose
Journal name Australasian Psychiatry   Check publisher's open access policy
ISSN 1039-8562
Publication date 2007-06
Sub-type Article (original research)
DOI 10.1080/10398560601147020
Volume 15
Issue 3
Start page 242
End page 244
Total pages 3
Place of publication Abingdon, United Kingdom
Publisher Taylor & Francis
Collection year 2008
Language eng
Subject 321021 Psychiatry
730211 Mental health
1103 Clinical Sciences
Formatted abstract
Objective: A case of anticholinergic delirium in a female adolescent is described, exploring the pharmacokinetic reasons for the prolonged time course and reviewing the management provided.

Conclusion: A 14 year old female hospitalised for depression ingested large quantities of promethazine and cyproheptadine. A severe anticholinergic delirium ensued which resolved after six days, much longer than the expected duration. The likely cause of the prolonged delirium was the interaction of promethazine and fluvoxamine through the inhibition of the CYP2D6 enzyme. The patient's young age, the severity of the poisoning and the use of drugs with anticholinergic properties to manage the delirium may also have contributed. The delirium may have been reversed had a cholinesterase inhibitor been provided soon after the overdose.
Keyword Anticholinergic delirium
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
2008 Higher Education Research Data Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 4 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 8 times in Scopus Article | Citations
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Created: Mon, 17 Mar 2008, 12:31:13 EST by Brenda Mason on behalf of Psychiatry - Royal Brisbane and Women's Hospital