A clinician's guide to predicting fluid responsiveness in critical illness: applied physiology and research methodology

Sturgess, D., Joyce, C., Marwick, T. H. and Venkatesh, B. (2007) A clinician's guide to predicting fluid responsiveness in critical illness: applied physiology and research methodology. Anaesthesia and Intensive Care, 35 5: 669-678.


Author Sturgess, D.
Joyce, C.
Marwick, T. H.
Venkatesh, B.
Title A clinician's guide to predicting fluid responsiveness in critical illness: applied physiology and research methodology
Journal name Anaesthesia and Intensive Care   Check publisher's open access policy
ISSN 0310-057X
Publication date 2007-10
Sub-type Critical review of research, literature review, critical commentary
Volume 35
Issue 5
Start page 669
End page 678
Total pages 10
Editor A. W. Duncan
Place of publication Melbourne, Vic., Australia
Publisher Australian Society of Anaesthetists
Collection year 2008
Language eng
Subject 321003 Cardiology (incl. Cardiovascular Diseases)
730106 Cardiovascular system and diseases
CX
Abstract Intravenous fluid administration is often used in critical care with the goal of improving haemodynamics and consequently tissue perfusion and oxygen delivery. while inotropic and vasoactive drugs are often necessary to correct haemodynamic instability, resuscitation usually begins with fluid therapy. As fluid challenge can result in clinical deterioration, the ability to predict haemodynamic response is desirable. In this way it might be possible to avoid unnecessary volume replacement in critically ill patients. Cardiac preload is a concept that accounts for the relationship between ventricular filling and stroke volume. It has been challenging to apply this concept to clinical practice. For this reason, the study of fluid responsiveness is of increasing research and clinical interest. The clinical application of predicting fluid responsiveness requires an understanding of relevant physiological principles. Furthennore, an improved understanding of these principles should assist the clinician in appraising published data, which has been characterised by significant methodological differences. This review aims to assist the clinician by detailing the physiological principles that underlie the prediction of fluid responsiveness in the critically ill. In addition, the potential importance of methodological differences in the current literature will be considered.
Keyword Fluid loading
Cardiac
Preload
Haemodynamic response
Critical illness
Q-Index Code CX

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
 
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