Canine DLA diversity: 1. New alleles and haplotypes

Kennedy, L. J., Barnes, A., Short, A., Brown, J. J., Lester, S., Seddon, J., Fleeman, L. M., Francino, O., Brkljacic, M., Knyazev, S., Happ, G. M. and Ollier, W. E. R. (2007) Canine DLA diversity: 1. New alleles and haplotypes. Tissue Antigens: Immune response genetics, 69 Suppl. 1: 272-288. doi:10.1111/j.1399-0039.2006.00779.x

Author Kennedy, L. J.
Barnes, A.
Short, A.
Brown, J. J.
Lester, S.
Seddon, J.
Fleeman, L. M.
Francino, O.
Brkljacic, M.
Knyazev, S.
Happ, G. M.
Ollier, W. E. R.
Title Canine DLA diversity: 1. New alleles and haplotypes
Journal name Tissue Antigens: Immune response genetics   Check publisher's open access policy
ISSN 0001-2815
Publication date 2007-04
Year available 2007
Sub-type Article (original research)
DOI 10.1111/j.1399-0039.2006.00779.x
Volume 69
Issue Suppl. 1
Start page 272
End page 288
Total pages 17
Editor J. McCluskey
Place of publication Oxford
Publisher Blackwell Publishing
Collection year 2008
Language eng
Subject C1
270202 Genome Structure
270203 Population and Ecological Genetics
780105 Biological sciences
Abstract The aim of this component was to establish the range of DLA diversity in as many dog breeds as possible. In particular, we wanted to collect breeds that had not previously been studied. Data were submitted of 937 dogs of over 80 different breeds, and these included 17 'new' breeds. Twenty-eight new alleles were identified including 21 DLA-DRB1, 2 DLA-DQA1 and 5 DLA-DQB1 alleles. These occurred in many new haplotype combinations. One haplotype was identified that appeared to lack DQB1. Two other haplotypes carry two DQB1 genes. It was clear that each dog breed has a restricted range of DLA alleles and haplotypes, and no breed had all 88 haplotypes identified in this study.
Keyword Cell Biology
Q-Index Code C1
Q-Index Status Confirmed Code

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Created: Tue, 11 Mar 2008, 14:43:03 EST by Maria Malgapo on behalf of Faculty Of Nat Resources, Agric & Veterinary Sc