Regional differences in the in vitro penetration of methylsalicylate through equine skin

Mills, P. C. and Cross, S. E. (2007) Regional differences in the in vitro penetration of methylsalicylate through equine skin. The Veterinary Journal, 173 1: 57-61. doi:10.1016/j.tvjl.2005.08.023


Author Mills, P. C.
Cross, S. E.
Title Regional differences in the in vitro penetration of methylsalicylate through equine skin
Journal name The Veterinary Journal   Check publisher's open access policy
ISSN 1090-0233; 532-2971
Publication date 2007-01
Year available 2007
Sub-type Article (original research)
DOI 10.1016/j.tvjl.2005.08.023
Volume 173
Issue 1
Start page 57
End page 61
Total pages 5
Editor A. J. Higgins
Place of publication Oxford, United Kingdom
Publisher Elsevier
Collection year 2008
Language eng
Subject 300501 Veterinary Medicine
300512 Pharmacology
730109 Surgical methods and procedures
780105 Biological sciences
C1
Abstract Commercial formulations of non-steroidal anti-inflammatory drugs (NSAIDs) are developed for human use but the extent to which they will pass through equine skin is unknown. Skin was harvested from five Thoroughbred geldings from the thorax, groin and leg (dorsal metacarpal) regions and frozen (-20 degrees C) until required. Two grams of methylsalicylate (Mesa) gel was applied to defrosted full-thickness samples in diffusion cells and the penetration of Mesa and its active metabolite, salicylate (Sa), through skin samples were measured over 24 h. Significantly higher (P <= 0.02) total salicylate (AUC; Mesa + Sa) penetrated through skin from the leg region (5491.3 h mg/L), compared to thorax (3710.7 h mg/L) and groin (3571.5 h mg/L). In addition, there was a significantly higher (P <= 0.01) rate of penetration of total Sa through leg skin in the first 6 It after application. It was concluded that the commercial formulation of Mesa would achieve therapeutic levels of total salicylate beneath sites of topical application, with a faster and more pronounced response through the leg region, compared to the upper body. (c) 2005 Elsevier Ltd. All rights reserved.
Keyword Veterinary Sciences
Horse
Transdermal methylsalicylate
Salicylate
In vitro
Deep Tissue Penetration
Percutaneous-absorption
Transfollicular Routes
Topical Penetration
Methyl Salicylate
Synovial-fluid
Sites
Drug
Hydrocortisone
Patches
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

 
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Created: Mon, 10 Mar 2008, 14:09:49 EST by Maria Malgapo on behalf of School of Veterinary Science