Growth rates and the prevalence and progression of scoliosis in short-statured children on Australian growth hormone treatment programmes

Day, Gregory A., McPhee, Ian Bruce, Batch, Jenny and Tomlinson, Francis H. (2007) Growth rates and the prevalence and progression of scoliosis in short-statured children on Australian growth hormone treatment programmes. Scoliosis, 2 3: . doi:10.1186/1748-7161-2-3


Author Day, Gregory A.
McPhee, Ian Bruce
Batch, Jenny
Tomlinson, Francis H.
Title Growth rates and the prevalence and progression of scoliosis in short-statured children on Australian growth hormone treatment programmes
Journal name Scoliosis   Check publisher's open access policy
ISSN 1748-7161
Publication date 2007-02-22
Sub-type Article (original research)
DOI 10.1186/1748-7161-2-3
Open Access Status DOI
Volume 2
Issue 3
Total pages 8
Editor H-R. Weiss
Place of publication London, U.K.
Publisher BioMed Central
Collection year 2008
Language eng
Subject 321019 Paediatrics
730114 Skeletal system and disorders (incl. arthritis)
C1
Formatted abstract
Study design and aim

This was a longitudinal chart review of a diverse group (cohort) of patients undergoing HGH (Human Growth Hormone) treatment. Clinical and radiological examinations were performed with the aim to identify the presence and progression of scoliosis.

Methods and cohort


185 patients were recruited and a database incorporating the age at commencement, dose and frequency of growth hormone treatment and growth charts was compiled from their Medical Records. The presence of any known syndrome and the clinical presence of scoliosis were included for analysis. Subsequently, skeletally immature patients identified with scoliosis were followed up over a period of a minimum four years and the radiologic type, progression and severity (Cobb angle) of scoliosis were recorded.

Results


Four (3.6%) of the 109 with idiopathic short stature or hormone deficiency had idiopathic scoliosis (within normal limits for a control population) and scoliosis progression was not prospectively observed. 13 (28.8%) of 45 with Turner syndrome had scoliosis radiologically similar to idiopathic scoliosis. 11 (48%) of 23 with varying syndromes, had scoliosis. In the entire cohort, the growth rates of those with and without scoliosis were not statistically different and HGH treatment was not ceased because of progression of scoliosis.

Conclusion


In this study, there was no evidence of HGH treatment being responsible for progression of scoliosis in a small number of non-syndromic patients (four). An incidental finding was that scoliosis, similar to the idiopathic type, appears to be more prevalent in Turner syndrome than previously believed.
Q-Index Code C1
Q-Index Status Confirmed Code
Additional Notes On-line publication

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
2008 Higher Education Research Data Collection
School of Medicine Publications
 
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Created: Fri, 07 Mar 2008, 20:13:28 EST