Validation of a Prediction Model to Estimate Health Utilities Index Mark 3 Utility Scores from WOMAC Index Scores in Patients with Osteoarthritis of the Hip

Marshall, Deborah, Pericak, Dan, Grootendorst, Paul, Gooch, Katherine, Faris, Peter, Frank, Cy, Bellamy, Nicholas, Torrance, George and Feeny, David (2008) Validation of a Prediction Model to Estimate Health Utilities Index Mark 3 Utility Scores from WOMAC Index Scores in Patients with Osteoarthritis of the Hip. Value in Health, 11 3: 470-477. doi:10.1111/j.1524-4733.2007.00258.x


Author Marshall, Deborah
Pericak, Dan
Grootendorst, Paul
Gooch, Katherine
Faris, Peter
Frank, Cy
Bellamy, Nicholas
Torrance, George
Feeny, David
Title Validation of a Prediction Model to Estimate Health Utilities Index Mark 3 Utility Scores from WOMAC Index Scores in Patients with Osteoarthritis of the Hip
Journal name Value in Health   Check publisher's open access policy
ISSN 1098-3015
Publication date 2008-05
Year available 2007
Sub-type Article (original research)
DOI 10.1111/j.1524-4733.2007.00258.x
Volume 11
Issue 3
Start page 470
End page 477
Total pages 8
Editor Josephine Mauskopf
Place of publication Lawrenceville, USA
Publisher Wiley-Blackwell Publishing Ltd
Collection year 2008
Language eng
Subject 321202 Epidemiology
730306 Evaluation of health outcomes
C1
Abstract Objective: To examine the validity of a newly developed prediction model translating osteoarthritis (OA)-specific health-related quality of life (HRQL) scores measured using the Western Ontario and McMaster Osteoarthritis Index (WOMAC) into generic utility-based HRQL scores measured using the Health Utilities Index Mark 3 (HUI3). Methods: Preintervention data from 145 patients with hip OA and complete WOMAC and HUI3 baseline assessments from the Alberta Hip Improvement Project study were used to validate three utility prediction models. These models were estimated using data from a previous study of knee OA patients. Predictive performance was assessed using the mean absolute prediction error (MAE) criterion and several other criteria. Results: The validation sample appeared healthier (on the basis of the HUI3 and WOMAC) than the subjects used toestimate the prediction models. Nevertheless, the validation sample outperformed the predictive performance of the model sample. The results from the validation sample support the conclusions from the original study in that the primary model identified during model development (a model using WOMAC subscales, their interactions, their square terms, age, OA duration, their square terms, and gender) performed better on the MAE criterion than competing models. Conclusion: These results support the external validity of the prediction model for the retrospective estimation of HUI3 utility scores for use in economic evaluation.
Formatted abstract
 Objective: To examine the validity of a newly developed prediction model translating osteoarthritis (OA)-specific health-related quality of life (HRQL) scores measured using the Western Ontario and McMaster Osteoarthritis Index (WOMAC) into generic utility-based HRQL scores measured using the Health Utilities Index Mark 3 (HUI3).

Methods: Preintervention data from 145 patients with hip OA and complete WOMAC and HUI3 baseline assessments from the Alberta Hip Improvement Project study were used to validate three utility prediction models. These models were estimated using data from a previous study of knee OA patients. Predictive performance was assessed using the mean absolute prediction error (MAE) criterion and several other criteria.

Results: The validation sample appeared healthier (on the basis of the HUI3 and WOMAC) than the subjects used toestimate the prediction models. Nevertheless, the validation sample outperformed the predictive performance of the model sample. The results from the validation sample support the conclusions from the original study in that the primary model identified during model development (a model using WOMAC subscales, their interactions, their square terms, age, OA duration, their square terms, and gender) performed better on the MAE criterion than competing models.

Conclusion: These results support the external validity of the prediction model for the retrospective estimation of HUI3 utility scores for use in economic evaluation.

Keyword Health Utilities Index
osteoarthritis
QALY
regression analysis
Western Ontario and McMaster Osteoarthritis (WOMAC) Index
Q-Index Code C1
Q-Index Status Confirmed Code
Additional Notes Published Online: 4 Sep 2007

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
2008 Higher Education Research Data Collection
School of Medicine Publications
 
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Created: Tue, 04 Mar 2008, 15:51:19 EST by Chesne McGrath on behalf of National Research on Disability and Rehabilitation Medicine