Radial pressure waveform dP/dt max is a poor indicator of left ventricular systolic function

Sharman, J., Qasem, A., Hanekom, L., Gill, D., Lim, R. and Marwick, T. H. (2007) Radial pressure waveform dP/dt max is a poor indicator of left ventricular systolic function. European Journal of Clinical Investigation, 37 4: 276-281. doi:10.1111/j.1365-2362.2007.01784.x

Author Sharman, J.
Qasem, A.
Hanekom, L.
Gill, D.
Lim, R.
Marwick, T. H.
Title Radial pressure waveform dP/dt max is a poor indicator of left ventricular systolic function
Journal name European Journal of Clinical Investigation   Check publisher's open access policy
ISSN 0014-2972
Publication date 2007
Sub-type Article (original research)
DOI 10.1111/j.1365-2362.2007.01784.x
Volume 37
Issue 4
Start page 276
End page 281
Total pages 6
Editor W. Hoerl
Place of publication Oxford
Publisher Blackwell Publishing Ltd.
Collection year 2008
Language eng
Subject 321003 Cardiology (incl. Cardiovascular Diseases)
730106 Cardiovascular system and diseases
110201 Cardiology (incl. Cardiovascular Diseases)
Formatted abstract
Background:  The first derivative of left ventricular (LV) pressure over time (dP/dt max) is a marker of LV systolic function that can be assessed during cardiac catheterization and echocardiography. Radial artery dP/dt max has been proposed as a possible marker of LV systolic function and we sought to test this hypothesis.

Materials and methods:
   We compared simultaneously recorded radial dP/dt max (by high-fidelity tonometry) with LV dP/dt max (by high-fidelity catheter and echocardiography parameters analogous to LV dP/dt max). In study 1, beat-to-beat radial dP/dt max and LV dP/dt max were recorded at rest and during supine exercise in 12 males (aged 61 +/- 12 years) undergoing cardiac catheterization. In study 2, 2D-echocardiography and radial dP/dt max were recorded in 54 patients (separate to study 1; 39 men; aged 64 +/- 10 years) at baseline and peak dobutamine-induced stress. Three basal septum measures were taken as being analogous to LV dP/dt max: 1. Peak systolic strain rate; 2. Strain rate (SR-dP/dt max) during isovolumic contraction (IVCT) and; 3. Tissue velocity during IVCT.

   In study 1 there was a significant difference between resting LV dP/dt max (1461 +/- 383 mmHg s(-1)) and radial dP/dt max (1182 +/- 319 mmHg s(-1); P < 0.001), and a poor, but statistically significant, correlation between the variables (R-2 = 0.006; P < 0.05). Similar results were observed during exercise. In study 2 there were weak (R-2 = -0.12; P = 0.01) to non-significant associations between radial dP/dt max and all echocardiographic measures analogous to LV dP/dt max at rest or peak stress.

   Radial pressure waveform dP/dt max is not a reliable marker of LV systolic function.
Keyword Medicine, General & Internal
Medicine, Research & Experimental
blood pressure
left ventricular function
radial artery
ventricular pressure
Central Aortic Pressure
Noninvasive Method
Pulse Pressure
Q-Index Code C1
Q-Index Status Confirmed Code

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
2008 Higher Education Research Data Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 11 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 15 times in Scopus Article | Citations
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Created: Tue, 04 Mar 2008, 12:53:53 EST by Denise Wilson on behalf of Medicine - Princess Alexandra Hospital