Synergistic interactions of the antiretroviral protease inhibitors saquinavir and ritonavir with chloroquine and mefloquine against Plasmodium falciparum in vitro

Skinner-Adams, T. S., Andrews, K. T., Melville, L., McCarthy, J. and Gardiner, D. L. (2007) Synergistic interactions of the antiretroviral protease inhibitors saquinavir and ritonavir with chloroquine and mefloquine against Plasmodium falciparum in vitro. Antimicrobial Agents and Chemotherapy, 51 2: 759-762. doi:10.1128/AAC.00840-06

Attached Files (Some files may be inaccessible until you login with your UQ eSpace credentials)
Name Description MIMEType Size Downloads
UQ131466_OA.pdf Full text (open access) application/pdf 207.79KB 0

Author Skinner-Adams, T. S.
Andrews, K. T.
Melville, L.
McCarthy, J.
Gardiner, D. L.
Title Synergistic interactions of the antiretroviral protease inhibitors saquinavir and ritonavir with chloroquine and mefloquine against Plasmodium falciparum in vitro
Formatted title
Synergistic interactions of the antiretroviral protease inhibitors saquinavir and ritonavir with chloroquine and mefloquine against Plasmodium falciparum in vitro
Journal name Antimicrobial Agents and Chemotherapy   Check publisher's open access policy
ISSN 0066-4804
Publication date 2007-02
Sub-type Article (original research)
DOI 10.1128/AAC.00840-06
Open Access Status File (Publisher version)
Volume 51
Issue 2
Start page 759
End page 762
Total pages 4
Editor G. M. Eliopoulos
Place of publication Washington, DC, United States
Publisher American Society for Microbiology
Collection year 2008
Language eng
Subject 320405 Medical Parasitology
730101 Infectious diseases
C1
Abstract The antimalarial activity of several antiretroviral protease inhibitor combinations was investigated. Data demonstrate that ritonavir and saquinavir behave synergistically with chloroquine and mefloquine. These data, and interactions with pepstatin-A, E-64, and bestatin, suggest that human immunodeficiency virus protease inhibitors do not target digestive-vacuole plasmepsins.
Keyword Animals
Antimalarials - pharmacology
Chloroquine - pharmacology
Drug Synergism
HIV Protease Inhibitors/pharmacology
Humans
Malaria, Falciparum/drug therapy
Mefloquine - pharmacology
Parasitic Sensitivity Tests
Plasmodium falciparum/*drug effects
Ritonavir - pharmacology
Saquinavir - pharmacology
Q-Index Code C1
Q-Index Status Confirmed Code

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
2008 Higher Education Research Data Collection
School of Medicine Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 31 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 41 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Mon, 03 Mar 2008, 11:30:20 EST