A longitudinal genetic study of uric Acid and liver enzymes in adolescent twins

Middelberg, Rita P. S., Medland, Sarah E., Martin, Nicholas G. and Whitfield, John B. (2007) A longitudinal genetic study of uric Acid and liver enzymes in adolescent twins. Twin Research and Human Genetics, 10 5: 757-764. doi:10.1375/twin.10.5.757

Author Middelberg, Rita P. S.
Medland, Sarah E.
Martin, Nicholas G.
Whitfield, John B.
Title A longitudinal genetic study of uric Acid and liver enzymes in adolescent twins
Journal name Twin Research and Human Genetics   Check publisher's open access policy
ISSN 1832-4274
Publication date 2007-10
Sub-type Article (original research)
DOI 10.1375/twin.10.5.757
Volume 10
Issue 5
Start page 757
End page 764
Total pages 8
Editor K. M. Kirk
N. G. Martin
Place of publication Bowen Hills, QLD, Australia
Publisher Australian Academic Press
Collection year 2008
Language eng
Subject 320303 Medical Biochemistry - Lipids
730106 Cardiovascular system and diseases
Abstract Biochemical traits such as plasma alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma glutamyltransferase (GGT) and uric acid are associated with obesity, and with risk of cardiovascular disease, metabolic syndrome and diabetes. Each is subject to genetic influences, but little is known about changes in genetic and environmental influences on these traits over time. We investigated the contribution of genetic and environmental influences to variation in these biochemical traits in adolescent twins and their nontwin siblings from 965 twin families. Twins were studied at ages 12, 14 and 16 years. Multivariate genetic models that included effects of age and sex were fitted to determine whether the same or different genetic or environmental factors influence each trait at different ages. Results showed that the genetic factors influencing AST, ALT, GGT and uric acid change over time during adolescence, and that the magnitude of these effects differs between males and females. The nonshared environment effects were generally time specific. There are developmental changes in genes affecting these traits during adolescence.
Keyword Genetics & Heredity
Obstetrics & Gynecology
Cardiovascular-disease Mortality
Pediatric Reference Intervals
Middle-aged Men
Metabolic Syndrome
Q-Index Code C1
Q-Index Status Confirmed Code

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Created: Mon, 03 Mar 2008, 11:26:45 EST