A haplotype spanning KIAA0319 and TTRAP is associated with normal variation in reading and spelling ability

Luciano, Michelle, Lind, Penelope A., Duffy, David L., Castles, Anne, Wright, Margaret J., Montgomery, Grant W., Martin, Nicholas G. and Bates, Timothy C. (2007) A haplotype spanning KIAA0319 and TTRAP is associated with normal variation in reading and spelling ability. Biological Psychiatry, 62 7: 811-817. doi:10.1016/j.biopsych.2007.03.007


Author Luciano, Michelle
Lind, Penelope A.
Duffy, David L.
Castles, Anne
Wright, Margaret J.
Montgomery, Grant W.
Martin, Nicholas G.
Bates, Timothy C.
Title A haplotype spanning KIAA0319 and TTRAP is associated with normal variation in reading and spelling ability
Formatted title
A haplotype spanning KIAA0319 and TTRAP is associated with normal variation in reading and spelling ability
Journal name Biological Psychiatry   Check publisher's open access policy
ISSN 0006-3223
1873-2402
Publication date 2007-10
Sub-type Article (original research)
DOI 10.1016/j.biopsych.2007.03.007
Volume 62
Issue 7
Start page 811
End page 817
Total pages 7
Editor D. S. Charney
Place of publication Philadelphia, PA, United States
Publisher Elsevier
Collection year 2008
Language eng
Subject 730107 Inherited diseases (incl. gene therapy)
321011 Medical Genetics
C1
Formatted abstract
Background

KIAA0319 (6p22.2) has recently been implicated as a susceptibility gene for dyslexia. We aimed to find further support for this gene by examining its association with reading and spelling ability in adolescent twins and their siblings unselected for dyslexia.

Methods


Ten single nucleotide polymorphisms (SNPs) in or near the KIAA0319 gene were typed in 440 families with up to five offspring who had been tested on reading and spelling tasks. Family-based association analyses were performed, including a univariate analysis of the principal component reading and spelling score derived from the Components of Reading Examination (CORE) test battery and a bivariate analysis of whole-word reading tests measured in a slightly larger sample.

Results


Significant association with rs2143340 (TTRAP) and rs6935076 (KIAA0319) and with a three-SNP haplotype spanning KIAA0319 and TTRAP was observed. The association with rs2143340 was found in both analyses, although the effect was in the opposite direction to that previously reported. The effect of rs6935076 on the principal component was in the same direction as past findings. Two of the three significant individual haplotypes showed effects in the opposite direction to the two prior reports.

Conclusions


These results suggest that a multilocus effect in or near KIAA0319 may influence variation in reading ability.

Keyword Family-based association
Haplotype analysis
KIAA0319
Reading ability
Spelling ability
TTRAP
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

 
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Created: Mon, 03 Mar 2008, 11:25:56 EST