Dizygotic twinning

Hoekstra, Chantal, Zhao, Zhen Zhen, Lambalk, Cornelius B., Willemsen, Gonneke, Martin, Nicholas G., Boomsma, Dorret I. and Montgomery, Grant W. (2008) Dizygotic twinning. Human Reproduction Update, 14 1: 37-47. doi:10.1093/humupd/dmm036

Author Hoekstra, Chantal
Zhao, Zhen Zhen
Lambalk, Cornelius B.
Willemsen, Gonneke
Martin, Nicholas G.
Boomsma, Dorret I.
Montgomery, Grant W.
Title Dizygotic twinning
Journal name Human Reproduction Update   Check publisher's open access policy
ISSN 1355-4786
Publication date 2008
Year available 2007
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1093/humupd/dmm036
Volume 14
Issue 1
Start page 37
End page 47
Total pages 11
Editor J. Collins
H. K. Beard
Place of publication Oxford, United Kingdom
Publisher Oxford University Press
Collection year 2008
Language eng
Subject 730107 Inherited diseases (incl. gene therapy)
321011 Medical Genetics
Abstract The tendency to conceive spontaneous dizygotic (DZ) twins is a complex trait with important contributions from both environmental factors and genetic disposition. Twins are relatively common and occur on average 13 times per 1000 maternities, though the twinning frequency varies over time and geographic location. This variation is mostly attributed to the differences in DZ twinning rate, since the monozygotic twinning rate is relatively constant. DZ twinning is in part under genetic control, with mothers of DZ twins reporting significantly more female family members with DZ twins than mothers of monozygotic twins. Maternal factors such as genetic history, advanced age and increased parity are known to increase the risk of DZ twins. Recent research confirmed that taller mothers and mothers with a high body mass index (30>) are at greater risk of DZ twinning. Seasonality, smoking, oral contraceptive use and folic acid show less convincing associations with twinning. Genetic analysis is beginning to identify genes contributing to the variation in twinning. Mutations in one of these genes (growth differentiation factor 9) are significantly more frequent in mothers of DZ twins. However, the mutations are rare and only account for a small part of the genetic contribution for twinning.
Keyword Age Factors
Intercellular Signaling Peptides and Proteins/genetics
Ovarian Failure, Premature/genetics
Reproductive Techniques, Assisted
Selection (Genetics)
*Twins, Dizygotic/genetics
Variation (Genetics)
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Excellence in Research Australia (ERA) - Collection
2008 Higher Education Research Data Collection
School of Medicine Publications
School of Psychology Publications
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Citation counts: TR Web of Science Citation Count  Cited 78 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 99 times in Scopus Article | Citations
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Created: Mon, 03 Mar 2008, 11:24:53 EST