Association of the gastric alcohol dehydrogenase gene Adh7 with variation in alcohol metabolism

Birley, Andrew J., James, Michael R., Dickson, Peter A., Montgomery, Grant W., Heath, Andrew C., Whitfield, John B. and Martin, Nicholas G. (2008) Association of the gastric alcohol dehydrogenase gene Adh7 with variation in alcohol metabolism. Human Molecular Genetics, 17 2: 179-189. doi:10.1093/hmg/ddm295


Author Birley, Andrew J.
James, Michael R.
Dickson, Peter A.
Montgomery, Grant W.
Heath, Andrew C.
Whitfield, John B.
Martin, Nicholas G.
Title Association of the gastric alcohol dehydrogenase gene Adh7 with variation in alcohol metabolism
Journal name Human Molecular Genetics   Check publisher's open access policy
ISSN 0964-6906
1460-2083
Publication date 2008
Year available 2007
Sub-type Article (original research)
DOI 10.1093/hmg/ddm295
Volume 17
Issue 2
Start page 179
End page 189
Total pages 11
Editor A. Wynshaw-Boris
K. Davies
Place of publication Oxford, United Kingdom
Publisher Oxford University Press
Collection year 2008
Language eng
Subject 730107 Inherited diseases (incl. gene therapy)
321011 Medical Genetics
C1
Abstract Seven alcohol metabolising enzymes are encoded by the human alcohol dehydrogenase (ADH) gene cluster on chromosome 4q22-23. One of these genes, ADH7, is uniquely expressed in the stomach mucosa and can influence metabolism of alcohol before its absorption into the blood. However, the contribution of ADH7to the overall genetic variation in alcohol oxidation in vivo is unknown. Data on in vivo alcohol metabolism were obtained for 206 Australian twin pairs of Caucasian ancestry, following ingestion of a standard dose (0.75g. kg(-1)body weight) of alcohol. Twenty-five single nucleotide polymorphisms that cover the ADH7 encoding region were genotyped. The patterns of linkage disequilibrium among these SNPs identified a recombinational hotspot within intron 7 of the ADH7 gene. A model for the absorption and elimination of alcohol from the body led to the identification of haplotypes associated with inter-individual variation in the early stages of alcohol metabolism. These are within a 35kb DNA tract contained in the region 5' of intron 7 in the ADH7 gene. The region accounts for 18% of the linkage for alcohol concentration associated with the ADH region, or approximately 11% of the genetic variance.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status Non-UQ

 
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Created: Mon, 03 Mar 2008, 11:23:43 EST