Estimation of variance components for age at menarche in twin families

Anderson, Carl A., Duffy, David L., Martin, Nicholas G. and Visscher, Peter M. (2007) Estimation of variance components for age at menarche in twin families. Behavior Genetics, 37 5: 668-677. doi:10.1007/s10519-007-9163-2


Author Anderson, Carl A.
Duffy, David L.
Martin, Nicholas G.
Visscher, Peter M.
Title Estimation of variance components for age at menarche in twin families
Journal name Behavior Genetics   Check publisher's open access policy
ISSN 0001-8244
1573-3297
Publication date 2007-08-07
Sub-type Article (original research)
DOI 10.1007/s10519-007-9163-2
Volume 37
Issue 5
Start page 668
End page 677
Total pages 10
Editor Dorret Boomsma
Place of publication New York, U.S.A.
Publisher Springer New York LLC
Collection year 2008
Language eng
Subject 730204 Child health
321011 Medical Genetics
C1
Abstract Age at menarche (AAM), time of first menstrual period, is an important developmental milestone in females. Follow-up data from 1,302 adolescent twins and their sisters were used to partition the normal variation in AAM. The proportion of censoring was 14.1%. Both a standard and a survival analysis method were used. The best fitting model from the survival analysis method was an ACE model, where 57% and 23% of the variance in AAM was explained by additive genetic and environmental effects, respectively. The best fitting model when using a standard variance decomposition method was an AE model, where 82% of the variance was explained by additive genetic effects. The lack of correspondence between the results of the two methods was an artefact of the different ascertainment of AAM reports from siblings and twins. After the removal of the sibling sample, both methods indicated that an ACE model was the most likely. Standard and survival analysis methods estimated the proportion of variance explained by additive effects to be 0.50 and 0.54, and common environmental effects to be 0.31 and 0.29, respectively. We conclude that variation in AAM can be explained by additive genetic and common environmental components.
Keyword Survival analysis
Age at menarche
Variance components
Frailty model
Censoring
Twin families
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
2008 Higher Education Research Data Collection
School of Medicine Publications
 
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Created: Mon, 03 Mar 2008, 11:23:21 EST