Abnormalities of left atrial function after cardioversion: an atrial strain rate study

Thomas, L., Mckay, T., Byth, K. and Marwick, T. H. (2007) Abnormalities of left atrial function after cardioversion: an atrial strain rate study. Heart, 93 1: 89-95. doi:10.1136/hrt.2006.088609

Author Thomas, L.
Mckay, T.
Byth, K.
Marwick, T. H.
Title Abnormalities of left atrial function after cardioversion: an atrial strain rate study
Journal name Heart   Check publisher's open access policy
ISSN 1355-6037
Publication date 2007
Year available 2006
Sub-type Article (original research)
DOI 10.1136/hrt.2006.088609
Volume 93
Issue 1
Start page 89
End page 95
Total pages 7
Editor Hall, R.J.
Place of publication U.K.
Publisher B.M.J. Publishing Group
Collection year 2008
Language eng
Subject C1
321003 Cardiology (incl. Cardiovascular Diseases)
730106 Cardiovascular system and diseases
Abstract Background and objectives: The role of atrial myocardial dysfunction after cardioversion is unclear. In a comparison of patients after successful cardioversion from chronic atrial fibrillation ( CAF) and normal controls, we sought to determine whether Doppler-derived atrial strain rate ( A-sr) could be used to measure global left atrial function and whether A-sr was reduced in patients with CAF. Methods: A-sr was measured from the basal septal, lateral, inferior and anterior atrial walls from the apical four-chamber and two-chamber views in 37 patients with CAF who had been cardioverted to sinus rhythm and followed up for 6 months, and in a cohort of 37 healthy people. Conventional measures of atrial function included peak transmitral A-wave velocity, A-wave velocity time integral, atrial fraction and the left atrial ejection fraction. Doppler tissue imaging was used to estimate atrial contraction velocity ( A' velocity). In addition to amplitude parameters, the time to peak A-sr was measured from aortic valve closure. Results: Immediately after cardioversion, A-sr in the CAF cohort ( baseline) was significantly lower than in controls ( mean ( SD) -0.53 ( 0.31) v -1.6 ( 0.75) s(-1); p < 0.001); the A-sr correlated with A' velocity ( r = 0.63; p < 0.001) in patients. Atrial function improved over time, with maximal change observed in the initial 4 weeks after cardioversion. The time to peak A-sr was increased in the CAF group compared with controls ( 0.55 ( 0.15) v 0.46 ( 0.12) s), but this failed to normalise over time. Conclusion: A-sr is a descriptor of atrial function, which is reduced after cardioversion from CAF and subsequently recovers.
Keyword Cardiac & Cardiovascular Systems
Regional Myocardial-function
Sinus Rhythm
Q-Index Code C1
Q-Index Status Confirmed Code
Additional Notes 2007 HERDC eligible - expanded publication year

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
2008 Higher Education Research Data Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 66 times in Thomson Reuters Web of Science Article | Citations
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Created: Thu, 28 Feb 2008, 11:37:24 EST by Denise Wilson on behalf of Medicine - Princess Alexandra Hospital