Non-B27 MHC associations of ankylosing spondylitis

Sims, A., Barnardo, M., Herzberg, I., Bradbury, L., Calin, A., Wordsworth, P. B., Drake, C. and Brown, M. A. (2007) Non-B27 MHC associations of ankylosing spondylitis. Genes and Immunity, 8 2: 115-123. doi:10.1038/sj.gene.6364362


Author Sims, A.
Barnardo, M.
Herzberg, I.
Bradbury, L.
Calin, A.
Wordsworth, P. B.
Drake, C.
Brown, M. A.
Title Non-B27 MHC associations of ankylosing spondylitis
Journal name Genes and Immunity   Check publisher's open access policy
ISSN 1466-4879
1476-5470
Publication date 2007
Sub-type Article (original research)
DOI 10.1038/sj.gene.6364362
Volume 8
Issue 2
Start page 115
End page 123
Total pages 9
Place of publication London, United Kingdom
Publisher Nature
Collection year 2008
Language eng
Abstract Ankylosing spondylitis (AS) has been associated with human leukocyte antigen (HLA)-B27 for over 30 years; however, the mechanism of action has remained elusive. Although many studies have reported associations between AS and other genes in the major histocompatibility complex (MHC) in AS, no conclusive results have emerged. To investigate the contribution of non-B27 MHC genes to AS, a large cohort of AS families and controls were B27 typed and genotyped across the region. Interrogation of the data identified a region of 270 kb, lying from 31 952 649 to 32 221 738 base pairs from the p-telomere of chromosome 6 and containing 23 genes, which is likely to include genes involved with susceptibility to AS.
Keyword Human leukocyte antigen
Immunology
Ankylosing spondylitis
Major histocompatibility complex
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

 
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Created: Tue, 19 Feb 2008, 14:39:14 EST