Childhood dairy intake and adult cancer risk: 65-y follow-up of the Boyd Orr cohort

van der Pols, J.C., Bain, C., Gunnell, D., Smith, G. D., Frobisher, C. and Martin, R. M. (2007) Childhood dairy intake and adult cancer risk: 65-y follow-up of the Boyd Orr cohort. American Journal of Clinical Nutrition, 86 6: 1722-1729.


Author van der Pols, J.C.
Bain, C.
Gunnell, D.
Smith, G. D.
Frobisher, C.
Martin, R. M.
Title Childhood dairy intake and adult cancer risk: 65-y follow-up of the Boyd Orr cohort
Journal name American Journal of Clinical Nutrition   Check publisher's open access policy
ISSN 0002-9165
Publication date 2007
Sub-type Article (original research)
Volume 86
Issue 6
Start page 1722
End page 1729
Total pages 8
Editor Bier, D.M.
Place of publication Bethesda, United States
Publisher American Society of Clinical Nutrition
Collection year 2008
Language eng
Subject C1
321205 Nutrition and Dietetics
730215 Nutrition
Abstract Background: Dairy consumption affects biological pathways associated with carcinogenesis. Evidence for a link between cancer risk and dairy consumption in adulthood is increasing, but associations with childhood dairy consumption have not been studied adequately. Objective: We investigated whether dairy consumption in childhood is associated with cancer incidence and mortality in adulthood. Design: From 1937 through 1939, some 4999 children living in England and Scotland participated in a study of family food consumption, assessed from 7-d household food inventories. The National Health Service central register was used to ascertain cancer registrations and deaths between 1948 and 2005 in the 4383 traced cohort members. Per capita household intake estimates for dairy products and calcium were used as proxy for individual intake. Results: During the follow-up period, 770 cancer registrations or cancer deaths occurred. High childhood total dairy intake was associated with a near-tripling in the odds of colorectal cancer [multivariate odds ratio: 2.90 (95% CI: 1.26, 6.65); 2-sided P for trend = 0.005] compared with low intake, independent of meat, fruit, and vegetable intakes and socioeconomic indicators. Milk intake showed a similar association with colorectal cancer risk. High milk intake was weakly inversely associated with prostate cancer risk (P for trend = 0.11). Childhood dairy intake was not associated with breast and stomach cancer risk; a positive association with lung cancer risk was confounded by smoking behavior during adulthood. Conclusions: A family diet rich in dairy products during childhood is associated with a greater risk of colorectal cancer in adulthood. Confirmation of possible underlying biological mechanisms is needed.
Keyword Nutrition & Dietetics
Dairy Products
Neoplasms
Life-course Analysis
Incidence
Mortality
United Kingdom
Growth-factor-i
Randomized Controlled-trial
Conjugated Linoleic-acid
Igf Binding Protein-3
Breast-cancer
Vitamin-d
Prostate-cancer
Colorectal-cancer
Polychlorinated-biphenyls
Cytochrome-p450 1a1
Q-Index Code C1
Q-Index Status Confirmed Code

 
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Created: Mon, 18 Feb 2008, 15:53:47 EST