The Australian Register of Antiepileptic Drugs in Pregnancy: The first 1002 pregnancies

Vajda, Frank J. E., Hitchcock, Alison, Graham, Janet, O'Brien, Terence, Lander, Cecilie and Eadie, Mervyn (2007) The Australian Register of Antiepileptic Drugs in Pregnancy: The first 1002 pregnancies. Australian and New Zealand Journal of Obstetrics and Gynaecology, 47 6: 468-474. doi:10.1111/j.1479-828X.2007.00781.x

Author Vajda, Frank J. E.
Hitchcock, Alison
Graham, Janet
O'Brien, Terence
Lander, Cecilie
Eadie, Mervyn
Title The Australian Register of Antiepileptic Drugs in Pregnancy: The first 1002 pregnancies
Journal name Australian and New Zealand Journal of Obstetrics and Gynaecology   Check publisher's open access policy
ISSN 0004-8666
Publication date 2007-12
Sub-type Article (original research)
DOI 10.1111/j.1479-828X.2007.00781.x
Volume 47
Issue 6
Start page 468
End page 474
Total pages 7
Place of publication Richmond, VIC, Australia
Publisher Wiley-Blackwell Publishing Asia
Language eng
Subject 11 Medical and Health Sciences
Formatted abstract
Prospective studies are needed to assess the maternal and fetal hazards of antiepileptic drug (AED) therapy in pregnancy.

To make the Australian Register of AEDs in Pregnancy better known to the Australian obstetric community by presenting results derived from it.

Analysis of data collected by the Register between 1999 and December 2006.

The Register contained data on 1002 epileptic or AED-treated pregnancies, 992 with known outcomes, 83 not exposed to AEDs in at least their first trimester, and 30 prescribed AEDs for indications other than epilepsy. Statistically significant findings included more frequent folate supplementation and decreased alcohol intake during pregnancy in women with epilepsy; a dose-related increased risk of fetal malformation associated with valproate therapy; a tendency towards lower birthweights in live-born malformed offspring; and a substantially reduced decreased risk of seizures in pregnancy with one year seizure freedom before pregnancy. The small numbers of patients may have prevented other differences from reaching a P < 0.05 value.

The Register has already produced important information for the management of pregnant women with epilepsy in Australia, but greater rates of recruitment into the Register are desirable to allow it to achieve its full potential.
Keyword Obstetrics and Gynecology
antiepileptic drugs
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
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Created: Mon, 18 Feb 2008, 15:36:09 EST