A Cluster-Randomized Bovine Intervention Trial against Schistosoma japonicum in the People’s Republic of China: Design and Baseline Results

Gray, Darren J., Williams, Gail M., Li, Yuesheng, Chen, Honggen, Li, Robert S., Forsyth, Simon J., Barnett, Adrian G., Guo, Jiagang, Feng, Zheng and McManus, Donald P. (2007) A Cluster-Randomized Bovine Intervention Trial against Schistosoma japonicum in the People’s Republic of China: Design and Baseline Results. American Journal of Tropical Medicine And Hygiene, 77 5: 866-874.


Author Gray, Darren J.
Williams, Gail M.
Li, Yuesheng
Chen, Honggen
Li, Robert S.
Forsyth, Simon J.
Barnett, Adrian G.
Guo, Jiagang
Feng, Zheng
McManus, Donald P.
Title A Cluster-Randomized Bovine Intervention Trial against Schistosoma japonicum in the People’s Republic of China: Design and Baseline Results
Formatted title A Cluster-Randomized Bovine Intervention Trial against Schistosoma japonicum in the People’s Republic of China: Design and Baseline Results
Journal name American Journal of Tropical Medicine And Hygiene   Check publisher's open access policy
ISSN 0002-9637
Publication date 2007
Sub-type Article (original research)
Volume 77
Issue 5
Start page 866
End page 874
Total pages 9
Editor J. W. Kazura
Place of publication Mclean
Publisher Amer Soc Trop Med & Hygiene
Collection year 2008
Language eng
Subject C1
320405 Medical Parasitology
730212 Disease distribution and transmission
Formatted abstract We describe the design and report baseline results of a cluster-randomized intervention to determine the importance of bovines for Schistosoma japonicum transmission in southern China. The study involves four matched village pairs in Hunan and Jiangxi Provinces, with a village within each pair randomly selected as intervention (human and bovine praziquantel treatment) or control (human praziquantel treatment only). Total study population prevalences at baseline were 12.4% (n = 5,390) and 15.2% (n = 1,573) for humans and bovines, respectively; village prevalences were similar within pairs. Bovine contamination index calculations showed that bovines less than 24 months of age were responsible for 74% of daily bovine environmental contamination with S. japonicum eggs. The village characteristics and baseline results underpin a rigorous study, which has major implications for deployment of a transmission-blocking bovine vaccine against S. japonicum. The combination of such a vaccine with other control strategies could potentially eliminate S. japonicum from southern China.
Keyword Public, Environmental & Occupational Health
Tropical Medicine
Poyang Lake
Praziquantel
Strategies
Resistance
Infection
Prospects
Vaccine
Region
Q-Index Code C1
Q-Index Status Confirmed Code

 
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