Modelling and simulation techniques for membrane biology

Burrage, K., Hancock, J., Leier, A. and Nicolau, D. V, (2007) Modelling and simulation techniques for membrane biology. Briefings In Bioinformatics, 8 4: 234-244. doi:10.1093/bib/bbm033


Author Burrage, K.
Hancock, J.
Leier, A.
Nicolau, D. V,
Title Modelling and simulation techniques for membrane biology
Journal name Briefings In Bioinformatics   Check publisher's open access policy
ISSN 1467-5463
Publication date 2007
Sub-type Article (original research)
DOI 10.1093/bib/bbm033
Volume 8
Issue 4
Start page 234
End page 244
Total pages 11
Place of publication Oxford
Publisher Oxford Univ Press
Language eng
Subject 060102 Bioinformatics
Abstract One of the most important aspects of Computational Cell Biology is the understanding of the complicated dynamical processes that take place on plasma membranes. These processes are often so complicated that purely temporal models cannot always adequately capture the dynamics. On the other hand, spatial models can have large computational overheads. In this article, we review some of these issues with respect to chemistry, membrane microdomains and anomalous diffusion and discuss how to select appropriate modelling and simulation paradigms based on some or all the following aspects: discrete, continuous, stochastic, delayed and complex spatial processes.
Keyword Biochemical Research Methods
Biotechnology & Applied Microbiology
spatial and stochastic modelling
bio-chemical kinetics
multi-scale simulation
systems biology
Fluorescence Correlation Spectroscopy
Stochastic Differential-equations
Single-particle Tracking
Monte-carlo Simulations
Anomalous Diffusion
Lipid Rafts
Cell-membranes
Reaction-kinetics
Mammalian-cells
Plasma-membrane
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
Institute for Molecular Bioscience - Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 24 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 25 times in Scopus Article | Citations
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Created: Mon, 18 Feb 2008, 15:34:14 EST