Aspirin and Lung Cancer Risk in a Cohort Study of Women: Dosage, Duration and Latency

Feskanich, D., Bain, C., Chan, A. T., Pandeya, N., Speizer, F. E. and Colditz, G. A. (2007) Aspirin and Lung Cancer Risk in a Cohort Study of Women: Dosage, Duration and Latency. British Journal of Cancer, 97 9: 1295-1299. doi:10.1038/sj.bjc.6603996


Author Feskanich, D.
Bain, C.
Chan, A. T.
Pandeya, N.
Speizer, F. E.
Colditz, G. A.
Title Aspirin and Lung Cancer Risk in a Cohort Study of Women: Dosage, Duration and Latency
Journal name British Journal of Cancer   Check publisher's open access policy
ISSN 0007-0920
1532-1827
Publication date 2007
Sub-type Article (original research)
DOI 10.1038/sj.bjc.6603996
Open Access Status DOI
Volume 97
Issue 9
Start page 1295
End page 1299
Total pages 5
Editor Harris, A.
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Collection year 2008
Language eng
Abstract Aspirin may reduce the risk of cancer at some sites but its effect at the lung is unclear. We prospectively examined associations between aspirin use and risk of lung cancer in 109 348 women in the Nurses' Health study from 1980 to 2004. During this time, 1360 lung cancers were documented in participants 36-82 years of age. Aspirin use and smoking were assessed every 2 years. Risk of lung cancer was a non-significant 16% lower for regular aspirin users of one or two tablets per week and a significant 55% higher for users of 15 or more tablets per week compared with women who never regularly used aspirin. Results were similar when limited to never smokers. For both the low and high quantity aspirin users, risk of lung cancer did not decline or increase with longer durations of use, and associations attenuated as the latency period between aspirin assessment and lung cancer diagnosis was lengthened. Our findings, together with those from previous clinical trials and prospective studies, do not provide consistent evidence that aspirin influences the development of lung cancer and further investigation is required with adjustment for smoking.
Keyword Oncology
Lung Cancer
Aspirin
Cohort
Women
Nonsteroidal Antiinflammatory Drugs
Low-dose Aspirin
Colorectal-cancer
Prevention
Users
Chemoprevention
Metaanalysis
Health
Trial
Colon
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

 
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Created: Mon, 18 Feb 2008, 15:30:39 EST