Pulmonary artery/aorta ratio in simple screening for fetal outflow tract abnormalities during the second trimester

Wong, S. F., Ward, C., Lee-Tannock, A., Le, S. and Chan, F. Y. (2007) Pulmonary artery/aorta ratio in simple screening for fetal outflow tract abnormalities during the second trimester. Ultrasound In Obstetrics & Gynecology, 30 3: 275-280. doi:10.1002/uog.4105


Author Wong, S. F.
Ward, C.
Lee-Tannock, A.
Le, S.
Chan, F. Y.
Title Pulmonary artery/aorta ratio in simple screening for fetal outflow tract abnormalities during the second trimester
Journal name Ultrasound In Obstetrics & Gynecology   Check publisher's open access policy
ISSN 0960-7692
1469-0705
1472-1201
Publication date 2007-09
Sub-type Article (original research)
DOI 10.1002/uog.4105
Volume 30
Issue 3
Start page 275
End page 280
Total pages 6
Place of publication Chichester, U.K.
Publisher John Wiley & Sons
Collection year 2008
Language eng
Subject C1
1114 Paediatrics and Reproductive Medicine
Formatted abstract
Objectives
Congenital heart disease is associated with high mortality and morbidity rates, being the most life-threatening defect in the first month of postnatal life and accounting for approximately half of all childhood mortality from birth defects. Despite this, the prenatal detection rate for congenital outflow tract anomalies by ultrasound imaging is relatively low. The aim of this study was to establish a nomogram for the pulmonary artery/aorta (PA/AO) ratio measured in the three-vessel view plane. This ratio was investigated as a simple screening tool for congenital cardiac outflow tract abnormalities.

Methods
The study was a prospective evaluation of 966 singleton fetuses at 16-24 weeks of gestation and 46 fetuses with congenital cardiac outflow tract abnormalities. The diameters of the pulmonary artery and aorta were measured in the three-vessel view. The PA/AO ratio was calculated and a nomogram was constructed. The mean and 95% CI for the ratio were defined and the PA/AO ratios of cases with outflow tract abnormalities were plotted against the values for normal fetuses.

Results
The gestational age of the normal group ranged from 16 to 24 weeks, with a median of 19 weeks. The pulmonary artery diameter measured between 2.1 and 4.93 mm (mean, 3.3 mm) and the aorta measured between 2.1 and 5.2 mm (mean, 2.93 mm). The mean (SD) PA/AO ratio was 1.16 (0.18) (95% Cl, 0.87-1.58; range 0. 61 -1.86; median, 1. 14). For fetuses with outflow tract abnormalities, the median gestation was 19 weeks and 37143 (86%) had a PA/AO ratio outside the 95% CI.

Conclusions
The PA/AO ratio derived from measurements in the three-vessel view plane can be used as an initial screening tool for outflow tract anomalies and may have a sensitivity of up to 86%, with a 5% false-positive rate.
Copyright © 2007 ISUOG.
Keyword Acoustics
Obstetrics & Gynecology
Radiology, Nuclear Medicine & Medical Imaging
congenital heart disease
fetal echocardiography
pregnancy
screening
ultrasound
Congenital Heart-disease
Prenatal-diagnosis
Great-arteries
4-chamber View
3-vessel View
Low-risk
Transposition
Fetuses
Echocardiography
Malformations
Q-Index Code C1
Q-Index Status Confirmed Code

 
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Created: Mon, 18 Feb 2008, 15:18:06 EST