A caspase-like gene from Heliothis virescens ascovirus (HvAV-3e) is not involved in apoptosis but is essential for virus replication

Asgari, S. (2007) A caspase-like gene from Heliothis virescens ascovirus (HvAV-3e) is not involved in apoptosis but is essential for virus replication. Virus Research, 128 1-2: 99-105.


Author Asgari, S.
Title A caspase-like gene from Heliothis virescens ascovirus (HvAV-3e) is not involved in apoptosis but is essential for virus replication
Formatted title A caspase-like gene from Heliothis virescens ascovirus (HvAV-3e) is not involved in apoptosis but is essential for virus replication
Journal name Virus Research   Check publisher's open access policy
ISSN 0168-1702
Publication date 2007
Sub-type Article (original research)
DOI 10.1016/j.virusres.2007.04.020
Volume 128
Issue 1-2
Start page 99
End page 105
Total pages 7
Editor B. W. J. Mahy
Place of publication Amsterdam
Publisher Elsevier Science Bv
Collection year 2008
Language eng
Subject 270303 Virology
C1
780105 Biological sciences
Abstract Ascoviruses (AVs) are double-stranded DNA viruses causing a fatal disease in lepidopteran host larvae. A unique feature of AV infection is cleavage of host cells into membrane bound vesicles containing the virions. A recent study showed that a caspase from Spodoptera frugiperda AV (SfAV) is directly involved in initiation of apoptosis and eventually cell cleavage. Results shown here indicate that Heliothis virescens AV does not induce apoptosis in host cells. HvAV codes for a caspase-like protein but no apoptosis was observed when the gene was expressed in vitro. RNAi studies indicated that the gene is essential for virus replication. (C) 2007 Elsevier B.V. All rights reserved.
Keyword Virology
ascovirus
Heliothis virescens ascovirus
caspase
apoptosis
vesicle formation
Cell-lines
Transmission
Organization
Infectivity
Sequence
Genome
Larvae
Q-Index Code C1

 
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Created: Mon, 18 Feb 2008, 15:00:16 EST