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A caspase-like gene from Heliothis virescens ascovirus (HvAV-3e) is not involved in apoptosis but is essential for virus replication
Asgari, S. (2007) A caspase-like gene from Heliothis virescens ascovirus (HvAV-3e) is not involved in apoptosis but is essential for virus replication. Virus Research, 128 1-2: 99-105.
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| Author(s) |
Asgari, S.
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| Title |
A caspase-like gene from Heliothis virescens ascovirus (HvAV-3e) is not involved in apoptosis but is essential for virus replication
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| Formatted title |
A caspase-like gene from Heliothis virescens ascovirus (HvAV-3e) is not involved in apoptosis but is essential for virus replication
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| Journal name |
Virus Research
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| Publication date |
2007
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| Volume number |
128
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| Issue number |
1-2
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| ISSN |
0168-1702
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| Start page |
99
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| End page |
105
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| Total pages |
7
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| Editor(s) |
B. W. J. Mahy
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| Place of publication |
Amsterdam
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| Publisher |
Elsevier Science Bv
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| Collection year |
2008
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| Language |
eng
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| Subject |
270303 Virology
C1
780105 Biological sciences
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| Abstract |
Ascoviruses (AVs) are double-stranded DNA viruses causing a fatal disease in lepidopteran host larvae. A unique feature of AV infection is cleavage of host cells into membrane bound vesicles containing the virions. A recent study showed that a caspase from Spodoptera frugiperda AV (SfAV) is directly involved in initiation of apoptosis and eventually cell cleavage. Results shown here indicate that Heliothis virescens AV does not induce apoptosis in host cells. HvAV codes for a caspase-like protein but no apoptosis was observed when the gene was expressed in vitro. RNAi studies indicated that the gene is essential for virus replication. (C) 2007 Elsevier B.V. All rights reserved.
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| Keyword(s) |
Virology
ascovirus
Heliothis virescens ascovirus
caspase
apoptosis
vesicle formation
Cell-lines
Transmission
Organization
Infectivity
Sequence
Genome
Larvae
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