Nonpharmacological treatment, fludrocortisone, and domperidone for orthostatic hypotension in Parkinson's disease

Schoffer, Kerrie L., Henderson, Robert D., O'Maley, Karen and O'Sullivan, John D. (2007) Nonpharmacological treatment, fludrocortisone, and domperidone for orthostatic hypotension in Parkinson's disease. Movement Disorders, 22 11: 1543-1549. doi:10.1002/mds.21428


Author Schoffer, Kerrie L.
Henderson, Robert D.
O'Maley, Karen
O'Sullivan, John D.
Title Nonpharmacological treatment, fludrocortisone, and domperidone for orthostatic hypotension in Parkinson's disease
Journal name Movement Disorders   Check publisher's open access policy
ISSN 0885-3185
Publication date 2007-06-07
Year available 2007
Sub-type Article (original research)
DOI 10.1002/mds.21428
Volume 22
Issue 11
Start page 1543
End page 1549
Total pages 7
Place of publication Hoboken, U.S.A.
Publisher John Wiley & Sons
Collection year 2008
Language eng
Subject 730104 Nervous system and disorders
320700 Neurosciences
C1
Abstract There is limited evidence for the treatment of orthostatic hypotension in idiopathic Parkinson's disease. The objective of this study was to determine the efficacy of three treatments (nonpharmacological therapy, fludrocortisone, and domperidone). Phase I assessed the compliance, safety, and efficacy of nonpharmacological measures. Phase II was a double-blind randomized controlled crossover trial of the two medications. Primary outcome measures consisted of the orthostatic domain of the Composite Autonomic Symptom Scale (COMPASS-OD), a clinical global impression of change (CGI), and postural blood pressure testing via bedside sphygmomanometry (Phase 1) or tilt table testing (Phase 11). For the 17 patients studied, nonpharmacological therapy did not significantly alter any outcome measure. Both medications improved the CGI and COMPASS-OD scores. There was a trend towards reduced blood pressure drop on tilt table testing, with domperidone having a greater effect. (c) 2007 Movement Disorder Society.
Keyword Clinical Neurology
orthostatic hypotension
Parkinson's disease
domperidone
nonpharmacological therapy
fludrocortisone.
Multiple System Atrophy
Postural Hypotension
Autonomic Dysfunction
Atherosclerosis Risk
Double-blind
Management
Efficacy
Placebo
Compression
Communities
Q-Index Code C1
Q-Index Status Confirmed Code

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
2008 Higher Education Research Data Collection
School of Medicine Publications
 
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Created: Mon, 18 Feb 2008, 14:57:51 EST