Coordination chemistry and biology of chelators for the treatment of iron overload disorders

Bernhardt, Paul V. (2007) Coordination chemistry and biology of chelators for the treatment of iron overload disorders. Dalton Transactions, 30: 3214-3220. doi:10.1039/b708133b

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Author Bernhardt, Paul V.
Title Coordination chemistry and biology of chelators for the treatment of iron overload disorders
Journal name Dalton Transactions   Check publisher's open access policy
ISSN 1477-9226
Publication date 2007
Sub-type Article (original research)
DOI 10.1039/b708133b
Open Access Status File (Publisher version)
Issue 30
Start page 3214
End page 3220
Total pages 7
Place of publication Cambridge
Publisher RSC Publications
Language eng
Subject CX
730118 Organs, diseases and abnormal conditions not elsewhere classified
250204 Bioinorganic Chemistry
Abstract Treatment of the medical condition generally referred to as iron overload through the delivery of chelators has recently received a major boost. In 2005 Novartis gained FDA approval for the drug deferasirox, which may be taken orally. Until this time most patients with Fe overload have had to endure long periods of subcutaneous infusions of the orally ineffective drug desferrioxamine (desferal) which has led to major problems with patient compliance. An effective Fe chelator must possess a number of properties for it to be able to complex Fe in vivo and be excreted intact. This Perspective will provide an overview of the current state of chelators for Fe overload; both those currently approved and those undergoing preclinical development.
Keyword Chemistry, Inorganic & Nuclear
Orally-active Chelator
Crystal-structure
Thalassemia Major
Deferiprone L1
Desferrioxamine-b
Complex-formation
Myocardial Iron
Ferrioxamine-b
Ligands
Therapy
Q-Index Code CX
Additional Notes This is a review article, it does not constitute original research for HERDC 2008 purposes.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Chemistry and Molecular Biosciences
 
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Created: Mon, 18 Feb 2008, 14:53:52 EST