Munc 18a: Munc-y business in mediating exocytosis

Latham, CF and Meunier, FA (2007) Munc 18a: Munc-y business in mediating exocytosis. International Journal of Biochemistry & Cell Biology, 39 9: 1576-1581. doi:10.1016/j.biocel.2006.11.015

Author Latham, CF
Meunier, FA
Title Munc 18a: Munc-y business in mediating exocytosis
Journal name International Journal of Biochemistry & Cell Biology   Check publisher's open access policy
ISSN 1357-2725
Publication date 2007
Sub-type Article (original research)
DOI 10.1016/j.biocel.2006.11.015
Volume 39
Issue 9
Start page 1576
End page 1581
Total pages 6
Place of publication Oxford
Publisher Pergamon-elsevier Science Ltd
Language eng
Abstract The precise sequence of molecular events underlying release of neurotransmitter in neurons is yet to be fully understood. This process, called exocytosis, is tightly controlled by a number of protein-protein and protein-lipid interactions. One such regulatory factor is Munc18a, a cytosolic protein characterized by its interaction with the molecular machinery of exocytosis, primarily with the target SNARE protein, syntaxin I a. While Munc18a interactions have been extensively investigated for more than a decade, the role of Munc18a in vesicular fusion is still not fully defined. In this review, we discuss: (i) the recent analysis of the role of Munc18a in tethering and docking, (ii) the known structural and (iii) functional data surrounding Munc18a interactions with numerous other proteins of the exocytic machinery. Integration of Munc18a regulation by phosphorylation and lipids and the apparent complexity of its pleiotropic functional interactions is critical to deciphering Munc18a's role in exocytosis. (c) 2006 Elsevier Ltd. All rights reserved.
Keyword Biochemistry & Molecular Biology
Cell Biology
Munc 18a
vesicle trafficking
SM protein
Cyclin-dependent Kinase-5
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Biomedical Sciences Publications
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Created: Mon, 18 Feb 2008, 14:53:04 EST