Calcium and cancer: targeting Ca2+ transport

Monteith, Gregory R., McAndrew, Damara, Faddy, Helen M. and Roberts-Thomson, Sarah J. (2007) Calcium and cancer: targeting Ca2+ transport. Nature Reviews Cancer, 7 7: 519-530. doi:10.1038/nrc2171


Author Monteith, Gregory R.
McAndrew, Damara
Faddy, Helen M.
Roberts-Thomson, Sarah J.
Title Calcium and cancer: targeting Ca2+ transport
Formatted title Calcium and cancer: targeting Ca2+ transport
Journal name Nature Reviews Cancer   Check publisher's open access policy
ISSN 1474-175X
Publication date 2007-07
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1038/nrc2171
Volume 7
Issue 7
Start page 519
End page 530
Total pages 12
Editor E. Hutchinson
Place of publication London
Publisher Nature Publishing Group
Collection year 2008
Language eng
Subject C1
320599 Pharmacology not elsewhere classified
780105 Biological sciences
Formatted abstract Ca2+ is a ubiquitous cellular signal. Altered expression of specific Ca2+ channels and pumps are characterizing features of some cancers. The ability of Ca2+ to regulate both cell death and proliferation, combined with the potential for pharmacological modulation, offers the opportunity for a set of new drug targets in cancer. However, the ubiquity of the Ca2+ signal is often mistakenly presumed to thwart the specific therapeutic targeting of proteins that transport Ca2+. This Review presents evidence to the contrary and addresses the question: which Ca2+ channels and pumps should be targeted?
Keyword Oncology
Inositol 1,4,5-trisphosphate Receptor
Membrane Ca2+-atpase Expression
Muscle Sarcoplasmic-reticulum
Messenger-rna Expression
Tumor-suppressor Genes
Human Prostate-cancer
Breast-cancer
Ryanodine Receptor
Endoplasmic-reticulum
Cell Carcinoma
Q-Index Code C1
Q-Index Status Confirmed Code

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Excellence in Research Australia (ERA) - Collection
2008 Higher Education Research Data Collection
School of Pharmacy Publications
 
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Created: Mon, 18 Feb 2008, 17:34:21 EST