An Unprecedented Fe-III(mu-OH)Zn-II Complex that Mimics the Structural and Functional Properties of Purple Acid Phosphatases

Neves, A., Lanznaster, M., Bortoluzzi, A. J., Peralta, R. A., Casellato, A., Castellano, E. E., Herrald, P., Riley, M. J. and Schenk, G. (2007) An Unprecedented Fe-III(mu-OH)Zn-II Complex that Mimics the Structural and Functional Properties of Purple Acid Phosphatases. Journal of The American Chemical Society, 129 24: 7486-7487. doi:10.1021/ja071184l


Author Neves, A.
Lanznaster, M.
Bortoluzzi, A. J.
Peralta, R. A.
Casellato, A.
Castellano, E. E.
Herrald, P.
Riley, M. J.
Schenk, G.
Title An Unprecedented Fe-III(mu-OH)Zn-II Complex that Mimics the Structural and Functional Properties of Purple Acid Phosphatases
Formatted title An Unprecedented Fe-III(mu-OH)Zn-II Complex that Mimics the Structural and Functional Properties of Purple Acid Phosphatases
Journal name Journal of The American Chemical Society   Check publisher's open access policy
ISSN 0002-7863
Publication date 2007-05-23
Sub-type Article (original research)
DOI 10.1021/ja071184l
Volume 129
Issue 24
Start page 7486
End page 7487
Total pages 2
Place of publication Washington
Publisher Amer Chemical Soc
Collection year 2008
Language eng
Subject 250100 Physical Chemistry (incl. Structural)
250105 Structural Chemistry
C1
270108 Enzymes
250302 Biological and Medical Chemistry
250204 Bioinorganic Chemistry
780103 Chemical sciences
Abstract This communication reports the synthesis and X-ray structure of the first mixed-valence (FeZnII)-Zn-III complex containing the Fe-III(mu-OH)Zn-II structural unit. Based on the structure, physicochemical solution studies, and the catalytic properties toward the hydrolysis of the diester 2,4-bis(dinitrophenyl)phosphate (BDNPP), it is proposed that complex 1 employs a hydrolytic mechanism similar to that proposed for red kidney bean purple acid phosphatase, including a nucleophilic attack by the terminal, Fe-III-bound hydroxide and the concomitant release of 2,4-dinitrophenolate. Furthermore, it is demonstrated that the mu-hydroxo group in the {Fe-III(mu-OH)(mu-ROPO3)Zn-II} intermediate is unable to hydrolyze the monoester 2,4-dinitrophenylphosphate (DNPP), which suggests that the mu-hydroxo group is a significantly poorer nucleophile than the terminally Fe-III-bound OH- group.
Keyword Chemistry, Multidisciplinary
Fe-mn Center
Crystal-structures
Bond
FeIII(μ-OH)ZnII
Q-Index Code C1
Q-Index Status Confirmed Code

 
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Created: Mon, 18 Feb 2008, 17:30:09 EST