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Aard is specifically up-regulated in Sertoli cells during mouse testis differentiation

Svingen, T., Beverdam, A., Verma, P., Wilhelm, D. and Koopman, P. (2007) Aard is specifically up-regulated in Sertoli cells during mouse testis differentiation. International Journal of Developmental Biology, 51 3: 255-258.


Author(s) Svingen, T.
Beverdam, A.
Verma, P.
Wilhelm, D.
Koopman, P.
Title Aard is specifically up-regulated in Sertoli cells during mouse testis differentiation
Journal name International Journal of Developmental Biology
Publication date 2007
Volume number 51
Issue number 3
ISSN 0214-6282
Start page 255
End page 258
Total pages 4
Place of publication Bilbao, Spain
Publisher U B C Press
Collection year 2008
Subject C1
270205 Genetic Development (incl. Sex Determination)
780105 Biological sciences
Abstract Aard (alanine and arginine rich domain) is a gene of unknown function, previously reported to show sexually dimorphic expression in fetal mouse gonads. Here we describe the spatio-temporal expression profile of Aard during gonad development. The period of elevated mRNA expression coincides with early differentiation of the testis and is limited to Sertoli cells of the developing testis cords. Although low levels of Aard transcripts were detected in other tissues by quantitative RT-PCR assays, high levels of Aard expression is specific to the testis in both embryonic and adult mice.
Keyword(s) Developmental Biology
aard
gonad
sex differentiation
testis cord
Sertoli cell
Sex Determination Reveals
Gene-expression
Germ-cells
Xx
 
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Created: Mon, 18 Feb 2008, 17:25:19 EST Detailed History