Preferential interactions of calcium ions in poly(2-hydroxyethyl methacrylate) hydrogels

Zainuddin, Hill, D. J. T., Whittaker, A. K., Lambert, L. and Chirila, T. V. (2007) Preferential interactions of calcium ions in poly(2-hydroxyethyl methacrylate) hydrogels. Journal of Materials Science: Materials in Medicine, 18 6: 1141-1149. doi:10.1007/s10856-007-0135-0

Author Zainuddin
Hill, D. J. T.
Whittaker, A. K.
Lambert, L.
Chirila, T. V.
Title Preferential interactions of calcium ions in poly(2-hydroxyethyl methacrylate) hydrogels
Journal name Journal of Materials Science: Materials in Medicine   Check publisher's open access policy
ISSN 0957-4530
Publication date 2007-02-01
Sub-type Article (original research)
DOI 10.1007/s10856-007-0135-0
Volume 18
Issue 6
Start page 1141
End page 1149
Total pages 9
Editor W. Bonfield
Place of publication Dordrecht
Publisher Springer
Collection year 2008
Language eng
Subject 250106 Mechanisms of Reactions
780103 Chemical sciences
Abstract An investigation of the preferential interaction of calcium ions with oxygen atoms in poly(2-hydroxyethyl methacrylate) (PHEMA)-based hydrogels has been carried out. The formation of polymer-Ca complexes was achieved by exposing powdered or fully hydrated samples with 5 mM, 0.1-0.5 M, or saturated CaCl2 solutions for certain periods of time. The characteristics of the polymer-Ca complexes were deduced from the effect of the solute on the equilibrium water content, and from NMR, atomic absorption and infrared spectroscopies. The absence of significant changes in the NMR chemical shift and infrared vibrational wavenumbers for the various functional groups confirmed that polymer complexation with Ca2+ ions involves only weak interactions, possibly electrostatic or ion-dipole interactions. Among the three types of oxygen atoms in PHEMA, hydroxyl oxygen atoms seem to be the most sensitive to the presence of Ca2+ ions. Complexation at the ester oxygen atoms was also evidenced by a new band in the infrared spectra at 1,550 cm(-1). On the other hand, there were no indications that the hydrophobic domains in the backbone and the methyl groups at the side chain of PHEMA interact significantly with Ca2+ ions.
Keyword Engineering, Biomedical
Materials Science, Biomaterials
Poly(glycol Monomethacrylate) Gel
Acrylic Hydrogels
Q-Index Code C1
Q-Index Status Confirmed Code

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Created: Mon, 18 Feb 2008, 17:15:27 EST